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Article
Open AccessCompound fermentation supernatants of antagonistic bacteria control Rhizoctonia cerealis and promote wheat growth
Wheat sheath blight, caused by Rhizoctonia cerealis, is a popular fungal disease that causes serious harm to wheat production. Biological control can offer the safe and effective method to control wheat diseases.
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Article
Open AccessUpregulation of miR-376c-3p alleviates oxygen–glucose deprivation-induced cell injury by targeting ING5
The expression level of miR-376c-3p is significantly lower in infants with neonatal hypoxic-ischemic encephalopathy (HIE) than in healthy infants. However, the biological function of this microRNA remains larg...
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Article
Open AccessAdministration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge
Monoclonal antibodies are one of the fastest growing classes of pharmaceutical products, however, their potential is limited by the high cost of development and manufacturing. Here we present a safe and cost-e...
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Article
Molecular tagging of a new broad-spectrum powdery mildew resistance allele Pm2c in Chinese wheat landrace Niaomai
A new broad-spectrum powdery mildew resistance allele Pm2c was identified and mapped in Chinese wheat landrace Niaomai.
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Article
Open AccessImproved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing
Fungi are important pathogens but challenging to enumerate using next-generation sequencing because of low absolute abundance in many samples and high levels of fungal DNA from contaminating sources.
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Chapter and Conference Paper
VvpGLT, a Grapevine Gene Encoding for a Plastidic Localized Glucose Transporter
Glucose transporters mediate the membrane transport of a variable range of glucose, which play a crucial role in sugar distribution throughout the plant. To investigate the significance of glucose transporters...
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Article
Open AccessDecreased plasticity of coreceptor use by CD4-independent SIV Envs that emerge in vivo
HIV and SIV generally require CD4 binding prior to coreceptor engagement, but Env can acquire the ability to use CCR5 independently of CD4 under various circumstances. The ability to use CCR5 coupled with low-...
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Article
Open AccessR5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies
Entry coreceptor use by HIV-1 plays a pivotal role in viral transmission, pathogenesis and disease progression. In many HIV-1 infected individuals, there is an expansion in coreceptor use from CCR5 to include ...
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Protocol
Use of Dual Recombinant Vaccinia Virus Vectors to Assay Viral Glycoprotein-Mediated Fusion with Transfection-Resistant Primary Cell Targets
Fusion mediated by the human immunodeficiency virus type-1 (HIV-1) envelope (Env) glycoprotein and the cellular CD4/chemokine receptor complex is the first step in entry and is often analyzed in cell-cell fusi...
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Article
Chemokine receptor utilization and macrophage signaling by human immunodeficiency virus type 1 gp120: Implications for neuropathogenesis
Human immunodeficiency virus type 1 (HIV-1) uses the chemokine receptors CCR5 and CXCR4 for entry. Macrophages and microglia (M/M) are the principal productively infected brain cells in HIV encephalopathy (HIV...
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Article
An unusual syncytia-inducing human immunodeficiency virus type 1 primary isolate from the central nervous system that is restricted to CXCR4, replicates efficiently in macrophages, and induces neuronal apoptosis
Macrophage/microglia cells are the principal targets for human immunodeficiency virus type 1 (HIV-1) in the central nervous system (CNS). Prototype HIV-1 isolates from the CNS are macrophage (M)-tropic, non-sy...
