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Article
Open AccessTumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer
Hematological metastasis has been recognized as a crucial factor contributing to the high rates of metastasis and mortality observed in colorectal cancer (CRC). Notably, exosomes derived from cancer cells part...
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Article
Open AccessA genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome
The nasal cavity harbors diverse microbiota that contributes to human health and respiratory diseases. However, whether and to what extent the host genome shapes the nasal microbiome remains largely unknown. H...
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Article
Open AccessAuthor Correction: Screening adequacy of unstained thyroid fine needle aspiration samples using a deep learning-based classifier
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Open AccessScreening adequacy of unstained thyroid fine needle aspiration samples using a deep learning-based classifier
Fine needle aspiration (FNA) biopsy of thyroid nodules is a safe, cost-effective, and accurate diagnostic method for detecting thyroid cancer. However, about 10% of initial FNA biopsy samples from patients are...
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Article
Earth Summit Mission 2022: Scientific Expedition and Research on Mt. Qomolangma Helps Reveal the Synergy between Westerly Winds and Monsoon and the Resulting Climatic and Environmental Effects
“Earth summit mission 2022” is one of the landmark scientific research activities of the Second Tibetan Plateau Scientific Expedition and Research (STEP). This scientific expedition firstly used advanced techn...
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Article
Optimal treatment of chronic kidney disease with uncertainty in obtaining a transplantable kidney: an MDP based approach
Chronic kidney disease (CKD) is one of the most serious and prevalent health issues all over the world. The evolution of CKD can last for many years until the death of patients, and the method of treatment mai...
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Article
METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p/BMPR1B axis
N6-methyladenosine (m6A) modification plays a crucial role in the progression of osteoporosis (OP). The study aimed to explore the effects of methyltransferase-like 3 (METTL3) in OP. The levels of METTL3, LINC...
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Article
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chines...
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Open AccessMetagenome-genome-wide association studies reveal human genetic impact on the oral microbiome
The oral microbiota contains billions of microbial cells, which could contribute to diseases in many body sites. Challenged by eating, drinking, and dental hygiene on a daily basis, the oral microbiota is rega...
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Open AccessA genome-wide association study for gut metagenome in Chinese adults illuminates complex diseases
The gut microbiome has been established as a key environmental factor to health. Genetic influences on the gut microbiome have been reported, yet, doubts remain as to the significance of genetic associations. ...
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Article
Comparison of the Pharmacokinetic Profiles of Ceftriaxone Used Alone and Combined with Danhong Injection in Old Rats
Danhong injection is the most commonly prescribed adjuvant drug applied for the treatment of cardiovascular and cerebrovascular diseases in China. Ceftriaxone is usually prescribed along with Danhong injection...
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Article
Tetramethylpyrazine Improves Postoperative Tissue Adhesion: A Drug Repurposing
Plants are known to possess plenty of pharmacological activities as a result of various phytoconstituents. Tetramethylpyrazine (TMP), one of the most widely used medicinal compound isolated from traditional Ch...
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Article
A novel method for concentration of porcine reproductive and respiratory syndrome virus from the environmental samples using self-aggregating peptide-tagged CD151-binding capture
Environmental surveillance of porcine reproductive and respiratory syndrome virus (PRRSV) represents a key issue in control of the disease. CD151 has recently been recognized as one of several receptors for PR...
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Article
Growth of 3D branched ZnO nanowire for DC-type piezoelectric nanogenerators
In this paper, we have demonstrated 3D branched ZnO nanotrees (ZNTs) on flexible ITO–PET substrates by a facile two-step hydrothermal approach. The characterization of the as-grown ZNTs was studied by using SE...
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Open AccessSATB1 Promotes Pancreatic Cancer Growth and Invasion Depending on MYC Activation
SATB1 plays an important role in human malignant progression, inducing cancer cell proliferation and metastasis by regulating downstream gene expressions. However, little is known about the underlying mechani...
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Article
Open AccessThe molecular basis for ethnic variation and histological subtype differences in prostate cancer
Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolv...
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Article
Adaptation or selection—mechanisms of castration-resistant prostate cancer
Men with prostate cancer often respond to androgen-deprivation therapy only to later relapse and develop lethal castration-resistant disease. Two models-adaptation and selection-have been described to explain ...
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Article
Open AccessDevelopment of a gene therapy strategy to target hepatocellular carcinoma based inhibition of protein phosphatase 2A using the α-fetoprotein promoter enhancer and pgk promoter: an in vitro and in vivo study
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Current therapies are insufficient, making HCC an intractable disease. Our previous studies confirmed that inhibi...
