-
Article
Open AccessCost-effectiveness of immunotherapies for advanced squamous non-small cell lung cancer: a systematic review
There are differences in the pharmacoeconomics of Immune checkpoint blocking (ICB) therapies for the treatment of lung squamous cell carcinoma (LSCC). However, no corresponding review studies have fully discus...
-
Article
LncRNA LENGA acts as a tumor suppressor in gastric cancer through BRD7/TP53 signaling
It has been established that long noncoding RNAs (lncRNAs) play a crucial role in various cancer types, and there are vast numbers of long noncoding RNA transcripts that have been identified by high-throughput...
-
Article
Open AccessComprehensive analysis of key genes and pathways for biological and clinical implications in thyroid-associated ophthalmopathy
Thyroid-associated ophthalmopathy (TAO) is a common and organ-specific autoimmune disease. Early diagnosis and novel treatments are essential to improve the prognosis of TAO patients. Therefore, the current wo...
-
Article
Open AccessGenomic signature of MTOR could be an immunogenicity marker in human colorectal cancer
The mTOR signaling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects pathway activity and the efficacy of mTOR inhibitor therapy. However, little research has been perfo...
-
Article
Open AccessOptineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling
Optineurin (OPTN) has important functions in diverse biological processes and diseases, but its effect on dendritic cell (DC) differentiation and functionality remains elusive. Here we show that OPTN is upregu...
-
Article
Open AccessNDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancer
N-myc downstream-regulated gene 1 (NDRG1) is a key regulator that interacts with many classic tumor signaling pathways, including some molecules downstream of the epidermal growth factor receptor (EGFR). Howev...
