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Article
Characterization of Calea ternifolia and its Adulterant Chromolaena odorata Using Macro-Microscopy, HPTLC and UHPLC-UV–MS
Calea ternifolia Kunth (syn. C. zacatechichi Schltdl.), Asteraceae, commonly known in English as dream herb, bitter-grass, or Mexican Calea, is a medicinal plant native to Mexico and Central America. It has long ...
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Article
Open AccessBreast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells
Gene expression signatures associated with breast cancer metastases suggest that metabolic re-wiring is important for metastatic growth in lungs, bones, and other organs. However, since pathway fluxes depend o...
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Article
Analysis of Crocetins and Safranal Variations in Saffron (Crocus sativus) Stigma Samples and Dietary Supplements Using HPLC/UHPLC-PDA-MS: Chemical Profiling and Chemometric Analysis Using LC-QToF
Saffron, the most expensive spice in the world, is comprised of the dried and dark red stigma of Crocus sativus L. flowers of the Iridaceae family. It is mainly used as a spice for imparting color, fragrance, and...
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Article
Optimized-dose lidocaine-loaded sulfobutyl ether β-cyclodextrin/hyaluronic acid hydrogels to improve physical, chemical, and pharmacological evaluation for local anesthetics and drug delivery systems
Local anesthetics (LAs) are a class of drugs, which have wide applications in the treatment of post-operative pain care management. Long-acting LAs that can be given as a single dose analgesic are desperately ...
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Article
Open AccessComparative pharmacokinetics and tissue distribution of primaquine enantiomers in mice
Primaquine (PQ) has been used for the radical cure of relapsing Plasmodium vivax malaria for more than 60 years. PQ is also recommended for prophylaxis and prevention of transmission of Plasmodium falciparum. How...
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Article
Open AccessThe effects of biodiversity gradient on plant mass and metabolism of individual submerged macrophytes
The effects of biodiversity on community function and services are frequently studied in the history of ecology, while the response of individual species to biodiversity remains great elusive. In this study, w...
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Article
Open AccessmicroRNA-1271-5p/TIAM1 suppresses the progression of ovarian cancer through inactivating Notch signaling pathway
Ovarian cancer (OC) has been regarded as the most malignant gynecological neoplasm and often confers grave outcomes owing to the frequent metastasis and high recurrence. A previous study has demonstrated that ...
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Article
Open AccessSuccessful treatment of mycobacterial infection associated hemophagocytic lymphohistiocytosis with etoposide and anti-tuberculous therapy: a case report
Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially life-threatening disorder characterized by an exacerbated but ineffective inflammatory response, which can be classified as primary and second...
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Article
Open AccessOut-of-pocket payments and economic consequences from tuberculosis care in eastern China: income inequality
Despite the availability of free tuberculosis (TB) diagnosis and treatment, TB care still generates substantial costs that push people into poverty. We investigated out-of-pocket (OOP) payments for TB care and...
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Article
Open AccessSkin Bleaching Among African and Afro-Caribbean Women in New York City: Primary Findings from a P30 Pilot Study
The application of skin bleaching products to inhibit melanogenesis is a common practice within the African diaspora. Despite the adverse health effects of skin bleaching, rigorous studies investigating skin b...
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Article
Open AccessFormation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes
The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P450-media...
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Article
Open AccessThe factors affecting a native obligate parasite, Cuscuta australis, in selecting an exotic weed, Humulus scandens, as its host
In weed management, using native parasites to control exotic weeds is considered a better alternative than classical biological control. But the risk must be assessed because of the potential damage caused by ...
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Article
Open AccessInfection-free rates and Sequelae predict factors in bone transportation for infected tibia: a systematic review and meta-analysis
Tibia infected nonunion and chronic osteomyelitis are challenging clinical presentations. Bone transportation with external or hybrid fixators (combined external and internal fixators) is versatile to solve th...
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Article
Negative relationship between diversity and productivity under plant invasion
The relationship between diversity and productivity of plant community under plant invasion has been not well known up to now. Here, we investigated the relationship between diversity and productivity under pl...
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Article
Open AccessMetabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry
Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabo...
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Article
CpG-ODNs and Budesonide Act Synergistically to Improve Allergic Responses in Combined Allergic Rhinitis and Asthma Syndrome Induced by Chronic Exposure to Ovalbumin by Modulating the TSLP-DC-OX40L Axis
The experimental model of combined allergic rhinitis and asthma syndrome (CARAS) has shown that CpG oligodeoxynucleotides (CpG-ODNs) are potential inhibitors of type 2 helper cell-driven inflammatory responses...
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Article
Open AccessEffects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis
It has been reported mesenchymal stem cells (MSCs) are recruited to and become integral parts of the tumor microenvironment. MSCs might have an active role in solid tumor progression, especially cancer metasta...
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Article
Open AccessM2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
M2-polarized macrophages are tumor-associated-macrophages (TAMs), which are important contents of tumor-infiltrating immune cells. Toll-like receptor 4 (TLR4) is a molecular biomarker of tumor aggressiveness a...
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Article
Open AccessAssociation between investigator-measured body-mass index and colorectal adenoma: a systematic review and meta-analysis of 168,201 subjects
The objective of this meta-analysis is to evaluate the odds of colorectal adenoma (CRA) in colorectal cancer screening participants with different body mass index (BMI) levels, and examine if this association ...
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Article
Open AccessPrognostic factors for mortality in patients with bullous pemphigoid: a meta-analysis
Bullous pemphigoid (BP) is a chronic debilitating autoimmune blistering disease that frequently occurs in the elderly population. Previous studies have suggested a high morbidity and mortality associated with ...
