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Real-time three-dimensional echocardiographic assessment of left ventricular remodeling index in patients with hypertensive heart disease and coronary artery disease
Left ventricular remodeling index (LVRI) was assessed in patients with hypertensive heart disease (HHD) and coronary artery disease (CAD) by real-time three-dimensional echocardiography (RT3DE). RT3DE data of ...
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Article
Wave intensity analysis of carotid artery: A noninvasive technique for assessing hemodynamic changes of hyperthyroid patients
This study examined the wave intensity (WI) of the carotid artery in patients with hyperthyroid in order to assess the hemodynamic changes of hyperthyroid patients. A total of 86 hyperthyroid patients without ...
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Article
Open AccessInsufficient maintenance DNA methylation is associated with abnormal embryonic development
Early pregnancy loss (EPL) is a frustrating clinical problem, whose mechanisms are not completely understood. DNA methylation, which includes maintenance methylation and de novo methylation directed by DNA methyl...
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Article
Hyperkalemia of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in hemodialysis: A meta-analysis
The safety of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) used in hemodialysis (HD) patients was evaluated. Medline, Embase, the Cochrane Library, some databases of...
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Article
Berberine inhibits norepinephrine-induced apoptosis in neonatal rat cardiomyocytes via inhibiting ROS-TNF-α-caspase signaling pathway
To determine the effect of berberine (Ber) on norepinephrine (NE)-induced apoptosis in neonatal rat cardiomyocytes.
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Article
Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats
To investigate the effect of Qindan Capsule (芩丹胶囊, QC) on collagen synthesis and the mechanism underlying the process in spontaneously hypertensive rats (SHRs).
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Article
Open AccessObjective assessment of urban built environment related to physical activity — development, reliability and validity of the China Urban Built Environment Scan Tool (CUBEST)
Some aspects of the neighborhood built environment may influence residents’ physical activity, which in turn, affects their health. This study aimed to develop an urban built environment evaluation tool and co...
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Article
Correlation between brachial artery flow-mediated dilation and endothelial microparticle levels for identifying endothelial dysfunction in children with Kawasaki disease
We investigated vascular endothelial dysfunction by sonographic features of flow-mediated dilation (FMD) and circulating endothelial microparticles (EMPs) in Kawasaki disease (KD).
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Open AccessAltered thyroid hormone profile in offspring after exposure to high estradiol environment during the first trimester of pregnancy: a cross-sectional study
The increasing number of babies conceived by in vitro fertilization and embryo transfer (IVF-ET) shifts concern from pregnancy outcomes to long-time health of offspring. Maternal high estradiol (E2) is a major ch...
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Article
Herbal medicine in the treatment of Alzheimer’s disease
Associated with the aging of our world population is a sharp increase in the incidence of Alzheimer’s disease, which not only poses a significant health issue but also presents a serious social problem. Althou...
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Article
Open AccessFamily influences on physical activity and sedentary behaviours in Chinese junior high school students: a cross-sectional study
Family influence plays an important role in a child’s physical activity (PA). This study aimed to describe the level of moderate to vigorous intensity physical activity (MVPA) and sedentary behaviours among Ch...
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Article
Association of serum Dkk-1 levels with β-catenin in patients with postmenopausal osteoporosis
Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 le...
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Article
Laser-induced interstitial thermotherapy via a single-needle delivery system: Optimal conditions of ablation, pathological and ultrasonic changes
This study aimed to examine the optimal conditions of laser-induced interstitial thermotherapy (LITT) via a single-needle delivery system, and the ablation-related pathological and ultrasonic changes. Ultrasou...
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Article
Effect of Qing’e formula on circulating sclerostin levels in patients with postmenopausal osteoporosis
Serum sclerostin is positively associated with serum 25 hydroxyvitamin D concentration. Our preliminary studies confirmed that Qing’e formula (QEF) could effectively increase serum 25 hydroxyvitamin D concentr...
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Article
Significance of normal range urinary albumin to creatinine ratio in Chinese subjects with metabolic syndrome
This study was aimed to investigate clinical features of Chinese metabolic syndrome (MS) subjects with normal urinary albumin to creatinine ratio (UACR) and to estimate independent correlation factor for UACR....
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Open AccessDiffusion magnetic resonance imaging study of schizophrenia in the context of abnormal neurodevelopment using multiple site data in a Chinese Han population
Schizophrenia has increasingly been considered a neurodevelopmental disorder, and the advancement of neuroimaging techniques and associated computational methods has enabled quantitative re-examination of this...
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Article
Over-expression of LRIG1 suppresses biological function of pituitary adenoma via attenuation of PI3K/AKT and Ras/Raf/ERK pathways in vivo and in vitro
Pituitary adenomas (PAs) are well known as a common intracranial benign tumor, and a portion of PAs are refractory to current therapeutic methods. ErbB receptors family signaling pathway regulates the expressi...
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Article
Open AccessRole of carbonyl sulfide in acute lung injury following limb ischemia/reperfusion in rats
To investigate the effect of carbonyl sulfide (COS) on limb ischemia/reperfusion (I/R)-induced acute lung injury (ALI) and the associated mechanism in rats.
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Article
Open AccessThe impact of insulin pump therapy to oxidative stress in patients with diabetic nephropathy
The oxidative stress resulting from increased production of ROS plays a crucial role in the development of diabetic complications. We aim to explore the relationships between oxidative stress, diabetic nephrop...
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Article
Open AccessGenetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations
Previous genome-wide association studies (GWAS) suggest that rs10489202 in the intron of MPC2 (mitochondrial pyruvate carrier 2) is a risk locus for schizophrenia in Han Chinese populations. To validate this disc...