10 Result(s)
within
Yan Qu
Life Sciences
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Article
The m6A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia
Persistent neuroinflammation and progressive neuronal loss are defining features of acute brain injury including traumatic brain injury (TBI) and cerebral stroke. Microglia, the most abundant type of brain-res...
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Open AccessFNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control
Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation. Although the Fibron...
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Article
Open AccessColoration differences in three Camellia reticulata Lindl. cultivars: ‘Tongzimian’, ‘Shizitou’ and ‘Damanao’
Camellia reticulata Lindl., also known as Yunnan Camellia, is an important ornamental plant in China, especially for its large and stunning flowers. A comprehensive understanding of their coloration mechanisms ca...
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Open AccessComparative proteomic profiling of plasma exosomes in lung cancer cases of liver and brain metastasis
Metastases within liver or the brain are the most common causes of mortality from lung cancer (LC). Predicting liver or brain metastases before having evidence from imaging of the tumors is challenging but imp...
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Open AccessSLC1A5 enhances malignant phenotypes through modulating ferroptosis status and immune microenvironment in glioma
Glioma is the most common type of primary malignant tumor in the central nervous system with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis is a nov...
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Article
Open AccessSiglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway
Pulmonary metastasis is the main cause of poor prognosis in osteosarcoma. Sialic acid-bound immunoglobulin lectin 15 (Siglec-15) has been demonstrated to be obviously correlated with pulmonary metastasis in os...
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Open AccessMesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis
Mesenchymal stem cells (MSCs) are a type of immunosuppressive stromal cell found in multiple tissues and organs. However, whether MSCs possess immunosupportive characteristics remains unclear. In this study, w...
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Physiological Responses of Highland Barley Seedlings to NaCl, Drought, and Freeze-Thaw Stress
Qinghai-Tibet plateau as an alpine and high-altitude area is frequently confronted with freeze-thaw stress. Recently, due to the change of global climate, the drought and salinization of soil in this area have...
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Open AccessPhenotypic Heterogeneity in a DFNA20/26 family segregating a novel ACTG1 mutation
Genetic factors play an important role in hearing loss, contributing to approximately 60 % of cases of congenital hearing loss. Autosomal dominant deafness accounts for approximately 20 % of cases of hereditar...
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Open AccessMonoterpenoid indole alkaloids from Alstonia rostrata
Four new monoterpenoid indole alkaloids, alstrostines C-F together with thirteen known alkaloids were isolated from the leaves and twigs of Alstonia rostrata. All structures of new compounds were elucidated based...
