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  1. No Access

    Article

    Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments

    FXIa has emerged as a promising therapeutic target for treating thrombotic diseases. With the aim to replace the aniline motif of asundexian with novel P2’ fragments, bicyclic isoquinoline and naphthalene ring...

    Yi Zhang, Linjun Dai, Yi Tan, Yongpeng Yu, Junhao **ng… in Medicinal Chemistry Research (2024)

  2. No Access

    Article

    Suppression of phosphorylated MAPK and caspase 3 by carbon dioxide

    Although CO2 is produced during the oxidation of different substrates in all types of cells, the role of this gas in the regulation of cellular function is not clearly understood. Since changes in several signal ...

    Yan-Jun Xu, Vijayan Elimban, Naranjan S. Dhalla in Molecular and Cellular Biochemistry (2017)

  3. No Access

    Article

    Effect of the Shenfu Injection Combined with Early Goal-Directed Therapy on Organ Functions and Outcomes of Septic Shock Patients

    Shenfu injection (SFI) derived from traditional Chinese medicine has been widely used in cardiovascular diseases. The objective of this study was to determine the effect of SFI and conventional early goal-dire...

    Mao-qin Li, Cui-gai Pan, **ao-meng Wang, Xun Mo… in Cell Biochemistry and Biophysics (2015)

  4. No Access

    Article

    Hemodiafiltration Combined with Resin-Mediated Absorption as a Therapy for Hyperlipidemic Acute Pancreatitis

    The aim of this study is to investigate whether hemodiafiltration combined with resin-mediated absorption is a better therapy for hyperlipidemic acute pancreatitis. Patients (n = 67) with acute pancreatitis treat...

    Mao-qin Li, Zai-xiang Shi, Ji-yuan Xu, Bo Lu… in Cell Biochemistry and Biophysics (2014)

  5. No Access

    Article

    Efficacy of Various Combined Blood Purification Techniques for Treating Patients with Non-viral Acute Liver Failure

    We sought to study the clinical efficacy of various combined blood purification techniques in patients with non-viral acute liver failure complicated by multiple organ dysfunction syndrome (MODS). For this pur...

    Mao-qin Li, Jia-qiong Li, Zai-xiang Shi, Ji-yuan Xu… in Cell Biochemistry and Biophysics (2014)

  6. No Access

    Chapter

    Modification of Biochemical and Cellular Processes in the Development of Atherosclerosis by Red Wine

    Harjot K. Saini, Parambir Dhami, Yan-Jun Xu… in Biochemistry of Atherosclerosis (2006)

  7. No Access

    Article

    Mechanisms of low Na+-induced increase in intracellular calcium in KCl-depolarized rat cardiomyocytes

    Although low Na+ is known to increase the intracellular Ca2+ concentration ([Ca2+]i) in cardiac muscle, the exact mechanisms of low Na+-induced increases in [Ca2+]i are not completely defined. To gain information...

    Satyajeet S. Rathi, Harjot K. Saini, Yan-Jun Xu… in Molecular and Cellular Biochemistry (2004)

  8. No Access

    Article

    Fura-2 fluorescent technique for the assessment of Ca2+ homeostasis in cardiomyocytes

    Ca2+ homeostasis plays a pivotal role in maintaining cell growth and function. Many heart diseases are related to the abnormalities in Ca2+ mobilization and extrusion. Ca2+-sensitive fluorescent dyes have been...

    Yan-Jun Xu, Qiming Shao, Naranjan S. Dhalla in Molecular and Cellular Biochemistry (1997)

  9. No Access

    Chapter

    Fura-2 fluorescent technique for the assessment of Ca2+ homeostasis in cardiomyocytes

    Ca2+ homeostasis plays a pivotal role in maintaining cell growth and function. Many heart diseases are related to the abnormalities in Ca2+ mobilization and extrusion. Ca2+-sensitive fluorescent dyes have been us...

    Yan-Jun Xu, Qiming Shao, Naranjan S. Dhalla in Novel Methods in Molecular and Cellular Bi… (1997)