5 Result(s)
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Article
Open AccessSuppression of HIV-1 replication by microRNA effectors
The rate of HIV-1 gene expression is a key step that determines the kinetics of virus spread and AIDS progression. Viral entry and gene expression were described to be the key determinants for cell permissiven...
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Article
RNAi Therapy for HIV Infection
Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs throu...
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Article
Open AccessHIV-1 Tat interaction with Dicer: requirement for RNA
Dicer is an RNase III which processes two classes of cellular small RNAs: the microRNAs (miRNA) and short interfering RNAs (siRNA). Previously, we observed that over-expressed HIV-1 Tat protein can suppress th...
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Article
Open AccessChanges in microRNA expression profiles in HIV-1-transfected human cells
MicroRNAs (miRNAs) are small RNAs of 18–25 nucleotides (nt) in length that play important roles in regulating a variety of biological processes. Recent studies suggest that cellular miRNAs may serve to control...
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Article
Open AccessHIV-1 encoded candidate micro-RNAs and their cellular targets
MicroRNAs (miRNAs) are small RNAs of 21–25 nucleotides that specifically regulate cellular gene expression at the post-transcriptional level. miRNAs are derived from the maturation by cellular RNases III of im...
