32 Result(s)
within
Yafang **ao
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMotif-based community detection in heterogeneous multilayer networks
Multilayer networks composed of intralayer edges and interlayer edges are an important type of complex networks. Considering the heterogeneity of nodes and edges, it is necessary to design more reasonable and ...
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Article
Open AccessIntegrative analysis of single-cell and bulk RNA-sequencing data revealed T cell marker genes based molecular sub-types and a prognostic signature in lung adenocarcinoma
Immunotherapy has emerged as a promising modality for addressing advanced or conventionally drug-resistant malignancies. When it comes to lung adenocarcinoma (LUAD), T cells have demonstrated significant influ...
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Article
Open AccessNetwork pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism
To explore the anti-tumor effects of Radix Astragali on osteosarcoma and its mechanism. We analyzed the PPI network of Radix Astragali’s potential targets for treating osteosarcoma and got the hub targets. We ...
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Article
Open AccessDynamic redox and nutrient cycling response to climate forcing in the Mesoproterozoic ocean
Controls on Mesoproterozoic ocean redox heterogeneity, and links to nutrient cycling and oxygenation feedbacks, remain poorly resolved. Here, we report ocean redox and phosphorus cycling across two high-resolu...
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Article
Open AccessMolecular insights into Spindlin1-HBx interplay and its impact on HBV transcription from cccDNA minichromosome
Molecular interplay between host epigenetic factors and viral proteins constitutes an intriguing mechanism for sustaining hepatitis B virus (HBV) life cycle and its chronic infection. HBV encodes a regulatory ...
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Article
Open AccessAccelerating the solar-thermal energy storage via inner-light supplying with optical waveguide
Solar-thermal storage with phase-change material (PCM) plays an important role in solar energy utilization. However, most PCMs own low thermal conductivity which restricts the thermal charging rate in bulk sam...
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Article
Open AccessUnified theoretical framework for black carbon mixing state allows greater accuracy of climate effect estimation
Black carbon (BC) plays an important role in the climate system because of its strong warming effect, yet the magnitude of this effect is highly uncertain owing to the complex mixing state of aerosols. Here we...
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Open AccessExpansion of human megakaryocyte-biased hematopoietic stem cells by biomimetic Microniche
Limited numbers of available hematopoietic stem cells (HSCs) limit the widespread use of HSC-based therapies. Expansion systems for functional heterogenous HSCs remain to be optimized. Here, we present a conve...
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Open AccessPivotal models and biomarkers related to the prognosis of breast cancer based on the immune cell interaction network
The effect of breast cancer heterogeneity on prognosis of patients is still unclear, especially the role of immune cells in prognosis of breast cancer. In this study, single cell transcriptome sequencing data ...
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Article
Open AccessSubversion of GBP-mediated host defense by E3 ligases acquired during Yersinia pestis evolution
Plague has caused three worldwide pandemics in history, including the Black Death in medieval ages. Yersinia pestis, the etiological agent of plague, has evolved a powerful arsenal to disrupt host immune defenses...
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Article
Open AccessThe value of Ki67 for the diagnosis of LSIL and the problems of p16 in the diagnosis of HSIL
p16 and Ki67 are immunohistochemical markers related to cervical squamous intraepithelial lesions. p16 has been widely used to assist in the diagnosis of high-grade squamous intraepithelial lesions. However, a...
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Article
Open AccessAerosol-boundary-layer-monsoon interactions amplify semi-direct effect of biomass smoke on low cloud formation in Southeast Asia
Low clouds play a key role in the Earth-atmosphere energy balance and influence agricultural production and solar-power generation. Smoke aloft has been found to enhance marine stratocumulus through aerosol-cl...
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Article
Open AccessThe expression and significance of AKR1B10 in laryngeal squamous cell carcinoma
Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification...
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Article
Open AccessCOVID-19 patients with hypertension are at potential risk of worsened organ injury
In less than 6 months, COVID-19 spread rapidly around the world and became a global health concern. Hypertension is the most common chronic disease in COVID-19 patients, but its impact on these patients has no...
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Article
Open AccessREV7 is required for processing AID initiated DNA lesions in activated B cells
Activation-induced cytidine deaminase (AID) initiates both antibody class switch recombination (CSR) and somatic hypermutation (SHM) in antibody diversification. DNA double-strand break response (DSBR) factors...
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Open AccessRobust closed-loop control of spike-and-wave discharges in a thalamocortical computational model of absence epilepsy
In this paper, we investigate the abatement of spike-and-wave discharges in a thalamocortical model using a closed-loop brain stimulation method. We first explore the complex states and various transitions in ...
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Article
Open AccessAcute kidney injury in cancer patients: A nationwide survey in China
Cancer patients have a high risk for acute kidney injury (AKI); however, the incidence, severity, and risk factors of malignancy-related AKI (MR-AKI) are unclear. This study aimed to assess MR-AKI risk factors...
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Open AccessFine map** of MHC region in lung cancer highlights independent susceptibility loci by ethnicity
The basis for associations between lung cancer and major histocompatibility complex genes is not completely understood. Here the authors further consider genetic variation within the MHC region in lung cancer ...
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Open AccessIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chr...
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Open AccessEffect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats
Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by the production of antibodies against acetylcholine receptors (AChRs). Qiangji Jianli (QJJL) decoction is an effective traditional ...
