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Article
Knockdown of EIF2AK2-OAS1 axis reduces ATP production inducing AMPK phosphorylation to inhibit the malignant behavior of gastric cancer cells
Energy metabolism has always been a hot topic in cancer progression and targeted therapy, and exploring the role of genes in energy metabolic pathways in cancer cells has become key to address this issue. Euka...
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Article
Contamination levels and ecological risk assessment of phthalate esters (PAEs) in the aquatic environment of Chaohu Lake
Phthalate esters (PAEs), widely recognized as synthetic organic compounds with extensive production and utilization, are known to disrupt physiological processes in both animals and humans, even at low environ...
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Article
An extended power geometric technique for multiple-attribute decision-making under single-valued neutrosophic sets and applications to embedded computers’ performance evaluation
Embedded computer systems refer to specialized computer systems that integrate operating systems and functional software into computer hardware systems, are application centric, based on computer technology, a...
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Article
Effect of Surface Roughness on the Properties of Ag/Cu Composite Strips
Ag/Cu composite strips with an alternating arrangement of 4 silver and 5 copper, which can be used as a fuse element, were successfully prepared by diffusion welding + cold rolling processes. The changing law ...
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Article
Risk factors and intervention of caregiver burden in Parkinson’s disease: a systematic review and meta-analysis
This study summarized characteristics and risk factors of caregiver burden in PD patients and used meta-analysis to verify the effectiveness of the intervention on caregiver burden.
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Article
Open AccessAdvances in the localization of pulmonary nodules: a comprehensive review
In recent years, with the widespread use of chest CT, the detection rate of pulmonary nodules has significantly increased (Abtin and Brown, J Clin Oncol 31:1002-8, 2013). Video-assisted thoracoscopic surgery (...
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Article
Open AccessQuantitative and dynamic profiling of human gut core microbiota by real-time PCR
The human gut microbiota refers to a diverse community of microorganisms that symbiotically exist in the human intestinal system. Altered microbial communities have been linked to many human pathologies. Howev...
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Article
Open AccessToxicity assessment of Cucurbita pepo cv Dayangua and its effects on gut microbiota in mice
Cucurbita pepo cv Dayangua (CPD) is an edible plant with diverse pharmacological properties. The current research on CPD has primarily focused on initial investigations of its chemical composition and pharmacolog...
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Article
Modulating and Imaging Macrophage Reprogramming for Cancer Immunotherapy
Cancer immunotherapy has made great progress in effectively attacking or eliminating cancer. However, the challenges posed by the low reactivity of some solid tumors still remain. Macrophages, as a key compone...
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Article
Open AccessA Lifetime of Work on Defect Modelling for Luminescence
To fully appreciate the contributions of Professor Watanabe to studies of luminescence, it is important to recall how, during his lifetime, not only have experimental facilities changed dramatically, but also ...
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Article
A label-free and rapid fluorometric strategy for microRNA detection using CRISPR-Cas12a coupled with copper nanoparticles
CRISPR-Cas12a with robust trans-cleavage activity were employed to mitigate background fluorescence signal, achieving sensitive detection of miRNA-21. The activation of trans-cleavage activity of Cas12a was ac...
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Article
Comparative Analysis of Digital Economy-Driven Innovation Development in China: An International Perspective
The emergence of e-commerce, digital technology, and the internet have all contributed to a revolutionary shift in the global landscape toward the digital economy, which is driving inventive development on a g...
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Article
Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma
CD39 serves as a crucial biomarker for neoantigen-specific CD8+ T cells and is associated with antitumor activity and exhaustion. However, the relationship between CD39 expression levels and the function of chime...
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Article
Formatted PVDF in lamellar composite solid electrolyte for solid-state lithium metal battery
Solid polymer electrolytes (SPEs) hold great application potential for solid-state lithium metal battery because of the excellent interfacial contact and processibility, but being hampered by the poor room-tem...
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Article
MELPD-Detector: Multi-level ensemble learning method based on adaptive data augmentation for Parkinson disease detection via free-KD
Parkinson disease (PD) is a neurodegenerative disorder which has tremor in the finger, handwriting change and so on. Tremor in the finger with PD changes the ty** pattern of subjects. Keystroke dynamics-base...
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Article
Open AccessLight-controlled crosslinked multifunctional "Band-Aids" as dual-stage wound dressing for dynamic wound closure
The objective of regenerative wound healing dressings is to accelerate skin tissue regeneration and restore normal physiological function at wound sites. Achieving this goal requires biomaterials capable of re...
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Article
Association between serum chloride and in-hospital mortality in congestive heart failure with diabetes: Data from the MIMIC-IV database
Congestive heart failure (CHF) demonstrates a heightened prevalence in individuals with diabetes mellitus within Intensive Care Units. The occurrence of abnormal chloride levels is frequently observed in criti...
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Article
Genome-wide elucidation and expression features of Q-type C2H2 zinc finger protein gene family in Rhododendron henanense subsp. lingbaoense
In plants, the C2H2 zinc-finger (C2H2-ZF) gene family is involved in various aspects of growth, development, and stress resistance. However, to date, no genome-wide identification, characterization, and expres...
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Article
Nanomaterials boost the biomedical application of synthetic biology
Synthetic biology applying genetic tools to engineer living cells and organisms, has burgeoning biomedical applications ranging from innovative biosensor and biomaterial design to the recent development of cli...
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Article
Open AccessComparative transcriptome analysis reveals major genes, transcription factors and biosynthetic pathways associated with leaf senescence in rice under different nitrogen application
Rice (Oryza sativa L.) is one of the most important food crops in the world and the application of nitrogen fertilizer is an effective means of ensuring stable and high rice yields. However, excessive application...
