83 Result(s)

Article

Large-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults

The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 uni...

Liu Yang, Ya-Nan Ou, Bang-Sheng Wu, Wei-Shi Liu, Yue-Ting Deng… in Nature Communications (2024)

Article

Chemo-, regio- and stereoselective access to polysubstituted 1,3-dienes via Nickel-catalyzed four-component reactions

1,2-Difunctionalization of alkynes offers a straightforward approach to access polysubstituted alkenes. However, simultaneous multi-component cascade transformations including difunctionalization of two alkyne...

Shanglin Chen, Ya-Nan Wang, **hui **e, Wangyang Li, Mingxing Ye… in Nature Communications (2024)

Article

Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA

Parental experiences can affect the phenotypic plasticity of offspring. In locusts, the population density that adults experience regulates the number and hatching synchrony of their eggs, contributing to locu...

Ya′nan Zhu, **g He, Jiawen Wang, Wei Guo, Hongran Liu… in Nature Communications (2024)

Article

CLK2 mediates IκBα-independent early termination of NF-κB activation by inducing cytoplasmic redistribution and degradation

Activation of the NF-κB pathway is strictly regulated to prevent excessive inflammatory and immune responses. In a well-known negative feedback model, IκBα-dependent NF-κB termination is a delayed response pat...

Shang-Ze Li, Qi-Peng Shu, Hai-Meng Zhou, Yu-Ying Liu, Meng-Qi Fan… in Nature Communications (2024)

Article

Stereoselective assembly of C-oligosaccharides via modular difunctionalization of glycals

C-oligosaccharides are found in natural products and drug molecules. Despite the considerable progress made during the last decades, modular and stereoselective synthesis of C-oligosaccharides continues to be ...

Ya-Nan Ding, Mei-Ze Xu, Yan-Chong Huang, Lutz Ackermann… in Nature Communications (2024)

Article

Phenotypic characterisation of regulatory T cells in patients with gestational diabetes mellitus

Gestational diabetes mellitus (GDM) is a common complication that occurs during pregnancy. Emerging evidence suggests that immune abnormalities play a pivotal role in the development of GDM. Specifically, regu...

Ya-nan Zhang, Qin Wu, Yi-hui Deng in Scientific Reports (2024)

Article

Comprehensive analyses of solute carrier family members identify SLC12A2 as a novel therapy target for colorectal cancer

As the largest transporter family impacting on tumor genesis and development, the prognostic value of solute carrier (SLC) members has not been elucidated in colorectal cancer (CRC). We aimed to identify a pro...

Dan-yang Chen, Yang-yang Zhang, Hai-hang Nie, Hai-zhou Wang… in Scientific Reports (2024)

Article

CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study

Epidemiological studies have reported a positive association between chronic inflammation and cancer risk. However, the causal association between chronic inflammation and breast cancer (BC) risk remains uncle...

Yongjia Cui, Shasha Cui, Wen** Lu, Ya’nan Wang, Zhili Zhuo… in Scientific Reports (2024)

Article

Hydrogen-bonded organic frameworks in solution enables continuous and high-crystalline membranes

Hydrogen-Bonded organic frameworks (HOFs) are a type of emerging porous materials. At present, little research has been conducted on their solution state. This work demonstrates that HOFs fragment into small p...

Qi Yin, Kuan Pang, Ya-Nan Feng, Lili Han, Ali Morsali, **-Ya Li… in Nature Communications (2024)

Article

A deep unrolled neural network for real-time MRI-guided brain intervention

Accurate navigation and targeting are critical for neurological interventions including biopsy and deep brain stimulation. Real-time image guidance further improves surgical planning and MRI is ideally suited ...

Zhao He, Ya-Nan Zhu, Yu Chen, Yi Chen, Yuchen He, Yuhao Sun… in Nature Communications (2023)

Article

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

As a major neuron type in the brain, the excitatory neuron (EN) regulates the lifespan in C. elegans. How the EN acquires senescence, however, is unknown. Here, we show that growth differentiation factor 11 (G...

Di-**an Wang, Zhao-Jun Dong, Sui-**n Deng, Ying-Ming Tian… in Nature Communications (2023)

Article

Distribution characteristics of organic carbon (nitrogen) content, cation exchange capacity, and specific surface area in different soil particle sizes

Understanding the distribution of soil organic carbon and nitrogen (OC(N)) content, cation exchange capacity (CEC), and specific surface area (SSA) in different soil particle sizes is crucial for studying soil...

**aoqian Bi, Hang Chu, Mingming Fu, Dandan Xu, Wenyu Zhao… in Scientific Reports (2023)

Article

GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression

Rapid eye movement (REM) sleep disturbances are prevalent in various psychiatric disorders. However, the neural circuits that regulate REM sleep remain poorly understood. Here, we found that in male mice, opto...

Ya-Nan Zhao, Jian-Bo Jiang, Shi-Yuan Tao, Yang Zhang, Ze-Ka Chen… in Nature Communications (2022)

Article

Azoarene activation for Schmidt-type reaction and mechanistic insights

The Schmidt rearrangement, a reaction that enables C-C or C-H σ bond cleavage and nitrogen insertion across an aldehyde or ketone substrate, is one of the most important and widely used synthetic tools for the...

Fan-Tao Meng, Ya-Nan Wang, **ao-Yan Qin, Shi-Jun Li, **g Li… in Nature Communications (2022)

Article

A wheat resistosome defines common principles of immune receptor channels

Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses¹. Indirect recognition of a pathogen effector by the dicotyledonous Arabidopsis th...

Alexander Förderer, Ertong Li, Aaron W. Lawson, Ya-nan Deng, Yue Sun… in Nature (2022)

Article

Inhibition of myeloid-derived suppressor cell arginase-1 production enhances T-cell-based immunotherapy against Cryptococcus neoformans infection

Cryptococcosis is a potentially lethal disease that is primarily caused by the fungus Cryptococcus neoformans, treatment options for cryptococcosis are limited. Here, we show glucuronoxylomannan, the major polysa...

Ya-Nan Li, Zhong-Wei Wang, Fan Li, Ling-Hong Zhou, Yan-Shan Jiang… in Nature Communications (2022)

Article

Molecular-docking-guided design, palladium-catalyzed synthesis and anticancer activity of paclitaxel-benzoxazoles hybrids

A series of new paclitaxel-benzoxazoles hybrids were designed based on both the molecular docking mode of beta-tubulin with paclitaxel derivatives (7a and 7g), and the activity-structure relationship of C-13 side...

Ting Jiang, Ya-Nan Cao, **-Bu Xu, Feng Gao, Ling-Li Zheng in Scientific Reports (2022)

Article

Insights into methionine S-methylation in diverse organisms

Dimethylsulfoniopropionate (DMSP) is an important marine anti-stress compound, with key roles in global nutrient cycling, chemotaxis and, potentially, climate regulation. Recently, diverse marine Actinobacteria,

Ming Peng, Chun-Yang Li, **u-Lan Chen, Beth T. Williams, Kang Li… in Nature Communications (2022)

Article

Addendum: Prostaglandin I₂ Attenuates Prostaglandin E₂-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism

Pu Wang, Pei-Pei Guan, **n Yu, Li-Chao Zhang, Ya-Nan Su… in Scientific Reports (2022)

Article

Diversity and dynamics of bacteria at the Chrysomya megacephala pupal stage revealed by third-generation sequencing

Characterization of the microbial community is essential for understanding the symbiotic relationships between microbes and host insects. Chrysomya megacephala is a vital resource, a forensic insect, a pollinator...

Wang Xu, Yu Wang, Ying-hui Wang, Ya-nan Zhang, Jiang-feng Wang in Scientific Reports (2022)