82 Result(s)

Article

Selective PI3Kδ inhibitor TYM-3-98 suppresses AKT/mTOR/SREBP1-mediated lipogenesis and promotes ferroptosis in KRAS-mutant colorectal cancer

Colorectal cancer (CRC) is one of the most common tumors of the digestive system worldwide. KRAS mutations limit the use of anti-EGFR antibodies in combination with chemotherapy for the treatment of CRC. There...

Ya-nan Zheng, Si-yue Lou, Jun Lu, Fan-li Zheng, Yong-mei Tang… in Cell Death & Disease (2024)

Article

CCL11 released by GSDMD-mediated macrophage pyroptosis regulates angiogenesis after hindlimb ischemia

Peripheral vascular disease (PVD) is an emerging public health burden with a high rate of disability and mortality. Gasdermin D (GSDMD) has been reported to exert pyroptosis and play a critical role in the pat...

Yiwen Wang, Yang Gao, Huairui Shi, Rifeng Gao, Ji’e Yang, Ya’nan Qu… in Cell Death Discovery (2024)

Article

Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge

The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental ischemia and poor perfusion which is strongly associated wi...

Jianjian Cui, Zejun Yang, Ruilin Ma, Wencong He, Hui Tao… in Stem Cell Reviews and Reports (2024)

Article

Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1–involved EMT in hepatocellular carcinoma

The protein annexin A6 (AnxA6) is involved in numerous membrane-related biological processes including cell migration and invasion by interacting with other proteins. The dysfunction of AnxA6, including protei...

Yanfang Yang, Lan Huang, Nan Zhang, Ya-Nan Deng, Xu Cao… in Cell Communication and Signaling (2024)

Article

Editorial Expression of Concern: HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs

Bin Zheng, Mei Han, Ya-nan Shu, Ying-jie Li, Sui-bing Miao, **n-hua Zhang… in Cell Research (2024)

Article

The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor

Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling pathways are mostly unknown. Aluminum (Al) ions are highly phyt...

Zhong Jie Ding, Chen Xu, **g Ying Yan, Yu Xuan Wang, Meng Qi Cui… in Cell Research (2024)

Article

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we...

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy

BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although ...

Zhi-Qiang Wang, Zhao-Cong Zhang, Yu-Yang Wu… in Signal Transduction and Targeted Therapy (2023)

Article

Water-saving techniques: physiological responses and regulatory mechanisms of crops

Water-saving irrigation techniques play a crucial role in addressing water scarcity challenges and promoting sustainable agriculture. However, the selection of appropriate water-saving irrigation methods remai...

Yu Chen, Ya-Nan Leng, Fu-Yuan Zhu, Si-En Li, Tao Song… in Advanced Biotechnology (2023)

Article

Kynureninase knockdown inhibits cisplatin resistance in vivo and in vitro and impacts the prognosis of cervical adenocarcinoma

Chemotherapy resistance is a leading cause of treatment failure in cases of cervical adenocarcinoma (ADC), and no effective treatment approach has yet been found. We previously identified the differentially ex...

Jun-wen Zhang, Ya-nan Wang, Mei-ling Zhong, Mei-rong Liang in Cell Division (2023)

Article

SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growth

The Annexin A6 (AnxA6) protein is known to inhibit the epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase (ERK)1/2 signaling upon EGF stimulation. While the biochemical mechanism of ...

Zenghua Sheng, Xu Cao, Ya-nan Deng, **nyu Zhao… in Cell Communication and Signaling (2023)

Article

PCK1 activates oncogenic autophagy via down-regulation Serine phosphorylation of UBAP2L and antagonizes colorectal cancer growth

Phosphoenolpyruvate carboxykinase 1 (PCK1) is the rate-limiting enzyme in gluconeogenesis. PCK1 is considered an anti-oncogene in several human cancers. In this study, we aimed to determine the functions of PC...

**angyan Zhang, Geru Tao, Jie Jiang, Tingting Qu, Shuchao Zhao… in Cancer Cell International (2023)

Article

Safety and immunogenicity of a mosaic vaccine booster against Omicron and other SARS-CoV-2 variants: a randomized phase 2 trial

An ongoing randomized, double-blind, controlled phase 2 trial was conducted to evaluate the safety and immunogenicity of a mosaic-type recombinant vaccine candidate, named NVSI-06-09, as a booster dose in subj...

Nawal Al Kaabi, Yun Kai Yang, Yu Liang, Ke Xu… in Signal Transduction and Targeted Therapy (2023)

Article

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Hong-Qing Zhang, Ya-Nan Zhang, Zhe-Rui Zhang… in Signal Transduction and Targeted Therapy (2022)