-
Article
Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients
Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-in...
-
Chapter
General Roles of Phytochelatins and Other Peptides in Plant Defense Mechanisms Against Oxidative Stress/Primary and Secondary Damages Induced by Heavy Metals
Phytochelatins (PCs) are nonprotein cysteine-rich oligopeptides having the general structure of (γ-glutamyl-cysteinyl)n-glycine (n = 2–11). They are synthesized from the precursor glutathione (a reduced form, GSH...
-
Article
Optimal timeline for emergency surgery in patients with strangulated groin hernias
This retrospective study evaluates the clinical course and outcomes of patients who underwent surgery for strangulated hernias.
-
Article
Open AccessSelf-production of tissue factor-coagulation factor VII complex by ovarian cancer cells
Thromboembolic events are a major complication in ovarian cancer patients. Tissue factor (TF) is frequently overexpressed in ovarian cancer tissue and correlates with intravascular thrombosis. TF binds to coag...
-
Article
Dynamics of redox related elements (Fe, Co, Zn, and Se) and oxidative stress caused by Se-deficiency in rats
The dynamics of redox related elements (Fe, Co, Zn, and Se) were studied using instrumental neutron activation analysis as a function of rat age in the range of 4 to 16 weeks. Activity levels of glutathione pe...
-
Article
Adhesion of binary giant vesicles containing negative spontaneous curvature lipids induced by phase separation
We report the adhesion of binary giant vesicles composed of two types of phospholipids, one has negative spontaneous curvature which tends to bend toward the head group and the other has zero spontaneous curva...
-
Article
Open AccessNovel heteroduplex method using small cytology specimens with a remarkably high success rate for analysing EGFR gene mutations with a significant correlation to gefitinib efficacy in non-small-cell lung cancer
We conducted a feasibility study to examine whether small numbers of cancer cells could be utilised for analysis of the EGFR gene status using the loop-hybrid mobility shift assay, which is a modified heterodu...
-
Article
Open AccessSite-controlled quantum dots fabricated using an atomic-force microscope assisted technique
An atomic-force microscope assisted technique is developed to control the position and size of self-assembled semiconductor quantum dots (QDs). Presently, the site precision is as good as ± 1.5 nm and the size...
-
Article
Open AccessPhase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN)
The aim of this study was to evaluate the efficacy and toxicity of a concurrent chemoradiotherapy using docetaxel, cisplatin and 5-fluorouracil (5-FU) (TPF) in patients with locally advanced squamous cell carc...
-
Article
Development of an environmental atmospheric tritium monitoring system at the Toki site
n this study, the application for monitoring atmospheric tritium at the site of nuclear fusion facility is presented. Construction and examination of the tritium sampler and its arrangement at the site are mai...
-
Article
Modulation of GnRH subtypes by social stress and aggressive behavior
The present study demonstrates that social dominance is a hierarchy of body size and that every adult male tilapia has the potential to become dominant depending upon the body size of his opponents. Further, w...
-
Article
Tritium separation from heavy water by electrolysis with solid polymer electrolyte
A tritium separation from heavy water by electrolysis using a solid polymer electrode layer was specified. The cathode was made of stainless steel or nickel. The electrolysis was performed for 1 hour at 5, 10,...
-
Article
Removal of the impurities from environmental water samples for tritium measurement by liquid scintillation counting
Liquid scintillation counting is the most popular method for tritium measurement, however, it takes much time and a lot of doing to distill off the impurities before mixing the sample water and liquid scintill...
-
Article
Mutation of the p51/p63 gene is associated with blastic crisis in chronic myelogenous leukemia
The p51/p63 gene, a novel member of the p53 gene family, has recently been identified at 3q27–9. There are at least six major isotypes of p51/p63 mRNA transcripts. p51A/TAp63γ has the potential to induce apopt...
-
Article
Fast Deposition of Microcrystalline Silicon Films Using The High-Density Microwave Plasma Utilizing a Spokewise Antenna
The high-density and low temperature microwave plasma utilizing a spokewise antenna was successfully applied to fast deposition of highly crystallized and photconductive microcrystalline silicon (μ-Si:H) films...
-
Article
Prostaglandin E2 (PGE2) Induces the c-fos and c-jun Expressions via the EP1 Subtype of PGE Receptor in Mouse Osteoblastic MC3T3-E1 Cells
This study examined which subtype(s) of PGE receptors is involved in the induction of c-fos and c-jun by PGE2 in MC3T3-E1 cells. We also investigated the possibility that the induction of these genes is involved...
-
Article
C-Type Natriuretic Peptide/Guanylate Cyclase B System in Rat Osteogenic ROB-C26 Cells and its Down-Regulation by Dexamethazone
There is recent evidence that natriuretic peptides are important regulators of bone and cartilage, although they were originally identified as the cardiac hormones causing natriuresis and hypotension. Three me...
-
Article
Expression and secretion of a biologically active mouse sonic hedgehog protein by the methylotrophic yeast Pichia pastoris
We have successfully secreted the amino-terminal functional domain of mouse sonic hedgehog protein (SHH) into culture fluid using a yeast Pichiapastoris expression system. A cDNA fragment encoding the amino-term...
-
Article
Prostaglandin E2 (PGE2) Autoamplifies its Production Through EP1 Subtype of PGE Receptor in Mouse Osteoblastic MC3T3-E1 Cells
Prostaglandin E2 (PGE2) is known to autoamplify its production in the osteoblasts through the induction of prostaglandin G/H synthase-2 (PGHS-2), which is the inducible form of the rate-limiting enzyme in PG syn...
-
Article
Regulation of forebrain and midbrain GnRH neurons in juvenile teleosts
Three molecular species of gonadotropin releasing hormone (GnRH) mRNA-containing neuronal populations (terminal nerve: salmon-GnRH; preoptic area: seabream-GnRH; midbrain: chic- ken-GnRH-II) have been localize...
