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  1. No Access

    Article

    Prandial Increases of Leptin and Orexin in the Brain Modulate Spatial Learning and Memory

    Leptin is well known to be involved in the inhibition of feeding, hermogenesis, reproduction, and neuroendocrine functions through its actions on the rodent’s hypothalamic receptors. Leptin facilitated the pre...

    Y. Oomura, S. Aou, K. Fukunaga, S. Moriguchi… in Neuroscience and Behavioral Physiology (2011)

  2. No Access

    Chapter

    Conformational and binding studies of the peptide isolated from phage display library by anti-mouse CTLA-4 monoclonal antibody

    Y. Ito, Y. Oomura, K. Ezaki, S. Kojima, T. Fukumoto… in Peptide Science — Present and Future (2002)

  3. No Access

    Chapter and Conference Paper

    Functional Correlation Between Feeding-Related Neurons and Chemical Senses

    Food and water intake are regulated by glucosesensitive neurons (GSNs) in the lateral hypothalamus (LHA); the firing rates of GSNs decrease in response to glucose administered by electrophoresis [1], and to me...

    Y. Oomura, Z. Karadi, H. Nishino, S. Aou, T. R. Scott in Olfaction and Taste XI (1994)

  4. No Access

    Chapter and Conference Paper

    Sensing of Endogenous Chemicals in Control of Feeding

    In addition to the receptors for the commonly considered senses — sight, taste, smell, ect. — there are receptors associated with our nervous system that respond qualitatively and quantitatively to endogenous ...

    Y. Oomura in Progress in Sensory Physiology 9 (1989)

  5. No Access

    Article

    Intracellular calcium ions decrease the affinity of the GABA receptor

    Intracellular free Ca2+ ([Ca2+]i) plays a crucial role in the transduction of extracellular signals1. It has been implicated in the modulation of light sensitivity in Limulus photoreceptors2 and in the efficacy o...

    M. Inoue, Y. Oomura, T. Yakushiji, N. Akaike in Nature (1986)

  6. No Access

    Article

    Bicuculline and picrotoxin block γ-aminobutryic acid-gated Cl− conductance by different mechanisms

    Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for γ-aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagoni...

    N. Akaike, K. Hattori, Y. Oomura, D. O. Carpenter in Experientia (1985)

  7. Article

    Insulin acting as a modulator of feeding through the hypothalamus

    To understand the functional role of insulin in the control of feeding, biochemical and physiological studies were performed in the rat.

    1. ...

    Y. Oomura, H. Kita in Diabetologia (1981)

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  8. No Access

    Article

    Inhibitory Action of the Amygdala on the Lateral Hypothalamic Area in Rats

    THE mammalian lateral hypothalamic area (LH) and the ventromedial hypothalamic nucleus (VMH) are involved in feeding and satiety function, respectively1. There is also reciprocity of electrical activity between t...

    Y. OOMURA, T. ONO, H. OOYAMA in Nature (1970)

  9. No Access

    Article

    Glucose and Osmosensitive Neurones of the Rat Hypothalamus

    THE lateral hypothalamic region (LH) is generally referred to as the feeding centre of the brain in the regulation of food intake, and many authors consider the ventromedial hypothalamic nucleus (VMH) to be th...

    Y. OOMURA, T. ONO, H. OOYAMA, M. J. WAYNER in Nature (1969)