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Article
Cytoskeleton disruption by the metabolic inhibitor 3-bromopyruvate: implications in cancer therapy
The small molecule 3-bromopyruvate (3BP), is an anticancer molecule that acts by hindering glycolysis and mitochondrial function leading to energy depletion and consequently, to cell death. In this work we hav...
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Article
The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside
At the beginning of the twenty-first century, 3-bromopyruvate (3BP), a simple alkylating chemical compound was presented to the scientific community as a potent anticancer agent, able to cause rapid toxicity t...
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Article
Prognostic relevance of pretransplant Deauville score on PET-CT and presence of EBV DNA in patients who underwent autologous stem cell transplantation for ENKTL
High-dose chemotherapy and autologous stem cell transplantation (ASCT) for extranodal natural killer/T-cell lymphoma (ENKTL) is a reasonable option for a subset of patients. The impact of response status, acco...
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Article
Open AccessJAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma
Epitheliotropic intestinal T-cell lymphoma (EITL, also known as type II enteropathy-associated T-cell lymphoma) is an aggressive intestinal disease with poor prognosis and its molecular alterations have not be...
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Article
Open AccessThe prognostic value of interim and end-of-treatment PET/CT in patients with newly diagnosed peripheral T-cell lymphoma
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Article
Type II EATL (epitheliotropic intestinal T-cell lymphoma): a neoplasm of intra-epithelial T-cells with predominant CD8αα phenotype
In this multicentre study, we examined 60 cases of Type II enteropathy-associated T-cell lymphoma (EATL) from the Asia-Pacific region by histological review, immunohistochemistry and molecular techniques. Pati...
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Article
Open AccessA translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside
The small alkylating molecule, 3-bromopyruvate (3BP), is a potent and specific anticancer agent. 3BP is different in its action from most currently available chemo-drugs. Thus, 3BP targets cancer cells’ energy...
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Article
Erratum: Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro
Correction to: Leukemia (2011) 25, 348–358 doi:10.1038/leu.2010.255 Since the publication of this paper, the authors have noticed an error in Supplementary Table 1. The ethnicity of the Jurkat cell line was in...
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Article
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro
Natural killer (NK) cell lymphomas/leukemias are rare neoplasms with an aggressive clinical behavior. The majority of the cases belong to extranodal NK/T-cell lymphoma, nasal type (ENKTL) in the current WHO cl...
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Article
Design of strain-compensated In x Ga1-x As/In y Al1-y As quantum cascade laser structures towards the shorter wavelengths
We design the In x Ga1-x As/InyAl1-yAs quantum cascade laser (QCL) structures, based on the four-quantum well active region with vertical transition with ...
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Article
Evaluation of ER and Ki-67 proliferation index as prognostic factors for survival following neoadjuvant chemotherapy with doxorubicin/docetaxel for locally advanced breast cancer
The aim of the study was to identify reliable predictive biological markers for treatment outcome following neoadjuvant adriamycin/docetaxel (AT) chemotherapy in locally advanced breast cancer patients.
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Article
Effects of Zn addition on the drop reliability of Sn–3.5Ag–xZn/Ni(P) solder joints
Varying amounts of Zn (1, 3, 7 wt%) were added to Sn–3.5Ag solder on the electroless Ni(P)/immersion Au metallization, and solder joint microstructures after reflow and isothermal aging (500 h at 150 °C) were ...
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Article
Effect of Zn on the intermetallics formation and reliability of Sn-3.5Ag solder on a Cu pad
Varying amounts of Zn (1, 3, and 7 wt%) were added to Sn–3.5Ag solder on a Cu pad, and the resultant solder joint microstructures after a reflow and isothermal aging (150 °C, up to 500 h) were investigated usi...
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Article
Protective effects of l-selenomethionine on space radiation induced changes in gene expression
Ionizing radiation can produce adverse biological effects in astronauts during space travel. Of particular concern are the types of radiation from highly energetic, heavy, charged particles known as HZE partic...
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Article
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This pheno...
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Article
The effect of Epstein–Barr virus status on clinical outcome in Hodgkin’s lymphoma
The association of Epstein–Barr virus (EBV) with Hodgkin’s lymphoma (HL) has been investigated over the last few years. The impact of EBV on clinical outcome is still controversial, however. In this study, we ...
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Article
Open AccessNasal-type NK/T cell lymphoma: clinical features and treatment outcome
Nasal-type NK/T cell lymphoma is an increasingly recognised disease entity of aggressive clinical behaviour. The objective of this study was to investigate clinical features and treatment outcomes in patients ...
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Article
Open AccessBRAF mutations in non-Hodgkin's lymphoma
Ras proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. BRAF, which encodes an RAF family member in the downstream pathway of RAS, i...
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Article
Autologous peripheral blood stem cell transplantation with induction of autologous graft-versus-host disease in acute myeloid leukemia
We studied whether the induction of autologous graft-versus-host disease (GVHD) has an antileukemic effect and consequently increases the survival of patients undergoing autologous peripheral blood stem cell t...
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Article
In vivo characterization of a prostate-specific antigen promoter-based suicide gene therapy for the treatment of benign prostatic hyperplasia
To develop a novel gene therapeutic modality for the effective treatment of benign prostatic hyperplasia (BPH), we investigated the properties of toxic gene therapy utilizing prostate-specific antigen (PSA) pr...
