17 Result(s)
within
Y Ohnishi
Biomedicine
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Article
Erratum: A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
Nat. Genet. 37, 478–485 (2005). In the replication study confirming the association between fcrl3_3 (−169C→T) and rheumatoid arthritis susceptibility, the allele frequency of fcrl3_3 in controls is 0.36.
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Open AccessBetulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice
We examined the antitumour effect of a combination of betulinic acid (BA) and vincristine (VCR) on murine melanoma B16F10 cells in vitro and in vivo. Betulinic acid, a pentacyclic triterpene, showed a synergistic...
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Article
Erratum: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction
Nature Genet. 32, 650–654 (2002). Published online 11 November 2002; doi:10.1038/ng1047 A typographical error in the third sentence of the abstract resulted in the P value for the association being incorrectly...
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Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190 562 genetic variations in the human genome
To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing ge...
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Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy
Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of unknown etiology and pathogenesis. Immunogenetic studies have not conclusively indicated that human leukocyte antigen (HLA) is in...
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Article
High-density single-nucleotide polymorphism (SNP) map in the 96-kb region containing the entire human DiGeorge syndrome critical region 2 (DGCR2) gene at 22q11.2
We constructed a high-density single-nucleotide polymorphism (SNP) map in the 96-kb region containing the DiGeorge syndrome critical region 2 (DGCR2) gene at chromosome 22q11.2, a human counterpart of mouse seiz...
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A high-throughput SNP ty** system for genome-wide association studies
One of the most difficult issues to be solved in genome-wide association studies is to reduce the amount of genomic DNA required for genoty**. Currently available technologies require too large a quantity o...
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Open AccessRibozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line
Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras functi...
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Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population
Single-nucleotide polymorphisms (SNPs) can make an important contribution to our understanding of genetic backgrounds that may influence medical conditions and ethnic diversity. We undertook a systematic surv...
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Identification of 187 single nucleotide polymorphisms (SNPs) among 41 candidate genes for ischemic heart disease in the Japanese population
To investigate whether common variants in the human genetic background are associated with pathogenesis of ischemic heart diseases, we systematically surveyed 41 possible candidate genes for single-nucleotide...
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Article
Murine P-glycoprotein on stromal vessels mediates multidrug resistance in intracerebral human glioma xenografts
Human glioma usually shows intrinsic multidrug resistance because of the blood-brain barrier (BBB), in which membrane-associated P-glycoprotein (P-gp), encoded by the human multidrug resistance gene MDR1, play...
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Article
P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo
We examined whether the increased expression of P-glycoprotein (P-gp) encoded by the human multidrug resistance gene MDR1 is related to the acquired multidrug resistance of lung cancer in vivo. We estimated th...
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Tyrosine phosphorylation of 100-130 kDa proteins in lung cancer correlates with poor prognosis
To search for the signalling pathways in lung cancer relevant to its aggressive behaviour, we studied tyrosine phosphorylated proteins in lung cancer cell lines and surgical specimens. We found that the profil...
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Article
In vitro and in vivo anti-tumour effects of a humanised monoclonal antibody against c-erbB-2 product
The c-erbB-2 product is thought to be a unique and useful target for antibody therapy of cancers overexpressing the c-erbB-2 gene. In vitro and in vivo anti-tumour effects of a humanised antibody against the e...
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Prolonged survival of mice with human gastric cancer treated with an anti-c-ErbB-2 monoclonal antibody
A monoclonal antibody (MAb), 4D5, specifically recognising an extracellular epitope of the c-ErbB-2 protein, inhibited the growth of human gastric cancer overexpressing c-ErbB-2 severe combined immunodeficient...
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Autonomous production of granulocyte-colony stimulating factor in tumour xenografts associated with leukocytosis
Leukocytosis sometimes accompanies malignant neoplasms in the absence of infection. It is thought that the production of colony-stimulating factor by neoplasms is the most potent cause of tumour-induced leukoc...
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An attempt of immunodiagnosis by means of mixed passive hemagglutination (MPHA) test for human pulmonary dirofilariasis
The mixed passive hemagglutination (MPHA) test was used for the first time in an attempt to diagnose human pulmonary dirofilariasis in a comparison with the results of ELISA. Eight of nine patients tested with...
