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  1. No Access

    Article

    Spring balance evaluation of the ischiocavernosus muscle

    We studied the voluntary contractile activity of the ischiocavernosus muscle (ICM) in 21 sexually potent and 97 erectile dysfunction (ED) subjects using a spring balance. A strap was placed around the coronal ...

    Y Kawanishi, T Kishimoto, K Kimura… in International Journal of Impotence Research (2001)

  2. Article

    Association analysis of polymorphisms in the prepronociceptin gene and schizophrenia

    The human prepronociceptin (ppNoc) gene is located on chromosome 8p21, and several linkage studies have suggested that the susceptibility locus for schizophrenia is present in this chromosomal region. We investi...

    K. Imai, S. Harada, Y. Kawanishi, H. Tachikawa, T. Okubo… in Journal of Human Genetics (2001)

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  3. No Access

    Article

    Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells

    We originally reported that vitamin K2 (VK2) analogs, including menaquinone 4 (MK4) but not vitamin K1, effectively induce apoptosis in various types of primary cultured leukemia cells and leukemia cell lines in ...

    K Miyazawa, M Yaguchi, K Funato, A Gotoh, Y Kawanishi, Y Nishizawa, A Yuo… in Leukemia (2001)

  4. No Access

    Article

    Screening of ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients

    Erection is a hemodynamic event and accordingly, erectile dysfunction (ED) is closely related with ischemic heart disease. We should confirm that the cardiac condition of the ED patient is safe enough to perfo...

    Y Kawanishi, KS Lee, K Kimura, T Koizumi… in International Journal of Impotence Research (2001)

  5. No Access

    Article

    Spontaneous reduction of leukemic lymphoma cells possibly by anti-tumor antibody-mediated phagocytosis; a κ λ-dual-positive B cell lymphoma

    We have investigated the possible role of anti-tumor antibody detected in a case of follicular lymphoma which demonstrated the spontaneous reduction of leukemic tumor cells. The tumor cells genotypically had m...

    M Nakano, Y Kawanishi, Y Kuriya ma, O Iwase, K Miyazawa, S Aizawa, I Yamasawa in Leukemia (2000)

  6. Article

    Novel polymorphisms of the AP-2 gene (6p24): Analysis of association with schizophrenia

    The transcription factor activator protein 2 (AP-2) gene is a possible candidate gene for schizophrenia, since it maps near D6S470, a marker on chromosome 6p24 that provided evidence of linkage to schizophrenia....

    Y. Kawanishi, S. Harada, H. Tachikawa, T. Okubo, H. Shiraishi in Journal of Human Genetics (2000)

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  7. Article

    Novel variants in the promoter region of the CREB gene in schizophrenic patients

    Cyclic AMP-responsive element-binding protein (CREB) is one of the messenger molecules involved in intracellular signal transduction pathways used by most dopamine and serotonin receptor subtypes. In addition...

    Y. Kawanishi, S. Harada, H. Tachikawa, T. Okubo, H. Shiraishi in Journal of Human Genetics (1999)

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  8. No Access

    Article

    Vitamin K2 induces apoptosis of a novel cell line established from a patient with myelodysplastic syndrome in blastic transformation

    We have previously reported that vitamin K2 (VK2) has a potent apoptosis inducing activity toward various types of primary cultured leukemia cells including acute myelogenous leukemia arising from myelodysplastic...

    J Nishimaki, K Miyazawa, M Yaguchi, T Katagiri, Y Kawanishi, K Toyama… in Leukemia (1999)

  9. No Access

    Article

    Vitamin K2 therapy for a patient with myelodysplastic syndrome

    M Yaguchi, K Miyazawa, M Otawa, Y Ito, Y Kawanishi, K Toyama in Leukemia (1999)

  10. No Access

    Article

    Vitamin K2 selectively induces apoptosis of blastic cells in myelodysplastic syndrome: flow cytometric detection of apoptotic cells using APO2.7 monoclonal antibody

    We have previously reported that vitamin K2 (VK2) but not VK1 has a potent apoptosis-inducing effect on freshly isolated leukemia cells from patients with various types of leukemia. By multi-color flow cytomet...

    M Yaguchi, K Miyazawa, M Otawa, T Katagiri, J Nishimaki, Y Uchida, O Iwase… in Leukemia (1998)

  11. No Access

    Article

    Effect of T cell subset dose on outcome of T cell-depleted bone marrow transplantation

    T cell depletion using the murine monoclonal antibody (moAb) T10B9 is unique in that the T cell receptor (TCR)γδbearing subset is relatively spared compared to the TCRαβ+ subset. We evaluated the probabilities of...

    Y Kawanishi, J Passweg, WR Drobyski, P Rowlings… in Bone Marrow Transplantation (1997)

  12. No Access

    Article

    Association of donor-derived host-reactive cytolytic and helper T cells with outcome following alternative donor T cell-depleted bone marrow transplantation

    Recipients of marrow from alternative donors (unrelated or HLA-mismatched related donors) have a higher incidence of post-transplant complications compared to recipients of marrow from HLA-identical siblings. ...

    CA Keever-Taylor, J Passweg, Y Kawanishi, J Casper… in Bone Marrow Transplantation (1997)

  13. No Access

    Article

    Evolutionary motif and its biological and structural significance

    We developed a method for multiple alignment of protein sequences. The main feature of this method is that it takes the evolutionary relationships of the proteins in question into account repeatedly for execut...

    Y. Tateno, K. Ikeo, T. Imanishi, H. Watanabe, T. Endo… in Journal of Molecular Evolution (1997)

  14. No Access

    Article

    Soluble Collagen in Bone

    CONSIDERABLE efforts have been made, so far, to investigate the physico-chemical as well as the biochemical nature of soft tissue collagen such as skin and tendon, especially. In refs. 1–3 it is suggested that...

    S. ARAYA, S. SAITO, S. NAKANISHI, Y. KAWANISHI in Nature (1961)