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  1. Article

    Open Access

    Optochemical control of slow-wave sleep in the nucleus accumbens of male mice by a photoactivatable allosteric modulator of adenosine A2A receptors

    Optochemistry, an emerging pharmacologic approach in which light is used to selectively activate or deactivate molecules, has the potential to alleviate symptoms, cure diseases, and improve quality of life whi...

    Koustav Roy, Xuzhao Zhou, Rintaro Otani, **-Chuan Yuan in Nature Communications (2024)

  2. Article

    Open Access

    Lateral septum adenosine A2A receptors control stress-induced depressive-like behaviors via signaling to the hypothalamus and habenula

    Major depressive disorder ranks as a major burden of disease worldwide, yet the current antidepressant medications are limited by frequent non-responsiveness and significant side effects. The lateral septum (L...

    Muran Wang, Peijun Li, Zewen Li, Beatriz S. da Silva, Wu Zheng in Nature Communications (2023)