44 Result(s)
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Article
Structure of the Bcr-Abl oncoprotein oligomerization domain
The Bcr-Abl oncoprotein is responsible for a wide range of human leukemias, including most cases of Philadelphia chromosome-positive chronic myelogenous leukemia. Oligomerization of Bcr-Abl is essential for on...
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Article
LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons
Granulocyte colony-stimulating factor (GCSF) is currently in clinical trials to treat neurodegenerative diseases and stroke. Here, we tested whether LIM domain only 4 protein (LMO4), a hypoxia-inducible gene t...
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Article
Open AccessAblation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism
The LIM domain only 4 (LMO4) protein is expressed in the hypothalamus, but its function there is not known. Using mice with LMO4 ablated in postnatal glutamatergic neurons, including most neurons of the parave...
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Diastereoselective Michael reaction of chiral nickel(II) glycinate with nitroalkenes for asymmetric synthesis of β-substituted α,γ-diaminobutyric acid derivatives in water
We have developed the first operationally simple and environmentally benign protocol for the aqueous asymmetric Michael addition reaction of chiral nickel(II) glycinate with nitroalkenes. The reactions proceed...
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Open AccessMetabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fat...
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Article
KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc
Cullin3 E3 ubiquitin ligase ubiquitinates a wide range of substrates through substrate-specific adaptors Bric-a-brac, Tramtrack, and Broad complex (BTB) domain proteins. These E3 ubiquitin ligase complexes are...
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Open AccessCisplatin-enriching cancer stem cells confer multidrug resistance in non-small cell lung cancer via enhancing TRIB1/HDAC activity
Chemotherapeutic agents are generally used as a frontline therapy for non-small cell lung cancer (NSCLC). However, resistance to chemotherapy arises rapidly in NSCLC, and the reasons for chemotherapy resistanc...
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Open AccessProtection of the biconcave profile of human erythrocytes against osmotic damage by ultraviolet-A irradiation through membrane-cytoskeleton enhancement
To perform various physiological functions, erythrocytes possess a unique biconcave shape provided by a special architecture of the membrane-skeleton system. In the present work, we use a simple irradiation me...
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Article
Analysis of neuronal phosphoproteome reveals PINK1 regulation of BAD function and cell death
PINK1 mutations that disrupt its kinase activity cause autosomal recessive early onset Parkinson’s disease (PD). Although research in recent years has elucidated a PINK1-Parkin pathway of mitophagy activation ...
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Open AccessSARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the SARS-CoV accessory protein open reading frames (SARS 3a) ...
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Open AccessIdelalisib promotes Bim-dependent apoptosis through AKT/FoxO3a in hepatocellular carcinoma
Idelalisib, a selective PI3Kδ inhibitor, has been approved by the FDA for chronic lymphocytic leukemia/small lymphocytic lymphoma treatment and for follicular lymphoma treatment when combined with rituximab. H...
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Open AccessGpr174-deficient regulatory T cells decrease cytokine storm in septic mice
G protein-coupled receptor 174 (GPR174) is mainly expressed in thymus, spleen, lymph nodes, and leukocytes, and genetic variation in GPR174 is associated with susceptibility to autoimmune diseases, indicating tha...
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Open AccessLy6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model
Most glioblastomas frequently recur at sites of radiotherapy, but it is unclear if changes in the tumor microenvironment due to radiotherapy influence glioblastoma recurrence. Here, we demonstrate that radiati...
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Open AccessHigh-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction
Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated the mechanism whereby long-term high-fat diet (HFD) feeding in...
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Article
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer
Estrogen receptor α (ERα) is the crucial factor in ERα-positive breast cancer progression. Endocrine therapies targeting ERα signaling is one of the widely used therapeutic strategies for breast cancer. Howeve...
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Open AccessInterleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections
Interleukin-38 has recently been shown to have anti-inflammatory properties in lung inflammatory diseases. However, the effects of IL-38 in viral pneumonia remains unknown. In the present study, we demonstrate...
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Open AccessInhibiting NLRP3 inflammasome activation prevents copper-induced neuropathology in a murine model of Wilson’s disease
Wilson’s disease (WD) is an inherited disorder characterized by excessive accumulation of copper in the body, particularly in the liver and brain. In the central nervous system (CNS), extracellular copper accu...
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Open AccessSequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1
Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) is downregulated in CHS cells treated with ...
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Open AccessSmoothened inhibition leads to decreased cell proliferation and suppressed tissue fibrosis in the development of benign prostatic hyperplasia
Benign prostatic hyperplasia (BPH) is a common disease in aging males. It has been proven that the Hedgehog (HH) is implied as an effective and fundamental regulatory growth factor signal for organogenesis, ho...
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Open AccessCircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis
Circular RNA (circRNAs) functions vital in the pathogenesis and progression of hepatocellular carcinoma (HCC). However, the expressions and functions of certain circRNAs on metastasis and proliferation of that...
