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  1. No Access

    Article

    Regional localization of the gene coding for sphingolipid activator protein SAP-1 on human chromosome 10

    Sphingolipid activator protein SAP-1 is required for the enzymatic hydrolysis of GMI ganglioside and sulfatide. The gene coding for SAP-1 was previously mapped to human chromosome 10 using monospecific antibod...

    Fa-Ten Kao, Martha Liao Law, Judith Hartz… in Somatic Cell and Molecular Genetics (1987)

  2. No Access

    Article

    Mutational analysis in a patient with a variant form of Gaucher disease caused by SAP-2 deficiency

    It is now clear that the lysosomal hydrolysis of sphingolipids requires both lysosomal enzymes and so-called sphingolipid activator proteins (SAPs). One gene, called prosaposin, codes for a precursor protein t...

    Mohammad A. Rafi, Gregory de Gala, Xun-ling Zhang… in Somatic Cell and Molecular Genetics (1993)

  3. Article

    Tissue-driven Hypothesis with Gene Ontology (GO) Analysis

    Most of the genes are under selective pressure to maintain their expression levels in the tissues. In a recent study, we have proposed a “tissue-driven” hypothesis stating that the stabilizing constraints on g...

    Zhixi Su, Yong Huang, Xun Gu in Annals of Biomedical Engineering (2007)

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  4. No Access

    Article

    Strong Genetic Differentiation of Primula sikkimensis in the East Himalaya–Hengduan Mountains

    The East Himalaya-Hengduan Mountains region is the center of diversity of the genus Primula, and P. sikkimensis is one of the most common members of the genus in the region. In this study, the genetic diversity a...

    Feng-Ying Wang, Xue-Jun Ge, Xun Gong, Chi-Ming Hu, Gang Hao in Biochemical Genetics (2008)

  5. No Access

    Article

    Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis

    Degterev et al. previously demonstrated that death receptor mediated apoptosis could be diverted to necroptosis when apoptosis signaling was blocked, suggesting that necroptosis may function as a backup mechan...

    Weidong Han, Jiansheng **e, Ling Li, Zhen Liu, Xun Hu in Apoptosis (2009)

  6. No Access

    Article

    Synthesis and primary evaluation of quinoxalinone derivatives as potent modulators of multidrug resistance

    P-glycoprotein-mediated drug efflux from cells is believed to be an important mechanism in multidrug resistance (MDR) in cancer chemotherapy. The identification and development of P-glycoprotein inhibitors wit...

    Hongyu Yuan, Xun Li, **anjun Qu, Lirui Sun, Wenfang Xu… in Medicinal Chemistry Research (2009)

  7. No Access

    Article

    Fluorescent Method for the Determination of Sulfide Anion with ZnS:Mn Quantum Dots

    Water-soluble Mn2+-doped ZnS quantum dots (QDs) were prepared using mercaptoacetic acid as the stabilizer. The optical properties and structure features were characterized by X-Ray, absorption spectrum, IR spectr...

    Bao-Hua Zhang, Fang-Ying Wu, Yu-Mei Wu, Xun-Shou Zhan in Journal of Fluorescence (2010)

  8. No Access

    Article

    Targeted Polymeric Micelle System for Delivery of Combretastatin A4 to Tumor Vasculature In Vitro

    To develop an efficient tumor vasculature-targeted polymeric micelle delivery system for combretastatin A4 (CA4), a novel antivascular agent.

    Yiguang Wang, Tingyuan Yang, Xun Wang, Jiancheng Wang… in Pharmaceutical Research (2010)

  9. No Access

    Article

    Inhalable Microparticles as Carriers for Pulmonary Delivery of Thymopentin-Loaded Solid Lipid Nanoparticles

    Microparticles containing solid lipid nanoparticles (SLNs) are receiving increased attention as carriers for the lung delivery of the SLNs. Thus, we aim to prepare the hybrid microparticles and thoroughly eval...

    Yan-Zhen Li, Xun Sun, Tao Gong, Jie Liu, Jiao Zuo… in Pharmaceutical Research (2010)

  10. No Access

    Article

    Solid Lipid Nanoparticles Loaded with Anti-microRNA Oligonucleotides (AMOs) for Suppression of MicroRNA-21 Functions in Human Lung Cancer Cells

    Literature has highlighted the practical use of solid lipid nanoparticles (SLNs) in research, but few reports have combined SLNs with miRNA-based therapy. We aimed to prepare SLNs to load anti-miRNA oligonucle...

    San-Jun Shi, Zhi-Rong Zhong, Jie Liu, Zhi-Rong Zhang, Xun Sun… in Pharmaceutical Research (2012)

  11. No Access

    Article

    Co-delivery of Adenovirus and Carmustine by Anionic Liposomes with Synergistic Anti-tumor Effects

    To improve gene transducibility mediated by adenovirus (Ad) in cancer cells and further enhance anti-tumor effects by co-delivery.

    Zhirong Zhong, Yu Wan, Sanjun Shi, Jianfeng Han, Zhirong Zhang… in Pharmaceutical Research (2012)

  12. No Access

    Article

    More discussions for granger causality and new causality measures

    Granger causality (GC) has been widely applied in economics and neuroscience to reveal causality influence of time series. In our previous paper (Hu et al., in IEEE Trans on Neural Netw, 22(6), pp. 829–844, 2011)...

    Sanqing Hu, Yu Cao, Jianhai Zhang, Wanzeng Kong, Kun Yang… in Cognitive Neurodynamics (2012)

  13. No Access

    Article

    Development of a Bionic System for the Simultaneous Prediction of the Release/Absorption Characteristics of Enteric-Coated Formulations

    To develop a new bionic system from an existing drug dissolution/absorption simulating system (DDASS) to simultaneously predict the release and absorption of enteric-coated formulations.

    Weijun Liu, **n He, Ziqiang Li, **umei Gao, Yetao Ma… in Pharmaceutical Research (2013)

  14. No Access

    Article

    The Implantable and Biodegradable PHBHHx 3D Scaffolds Loaded with Protein-Phospholipid Complex for Sustained Delivery of Proteins

    PHBHHx (poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)) is an excellent biomaterial for tissue repair. Here, we aim to develop a PHBHHx-based three-dimensional (3D) scaffold system for sustained delivery of pro...

    Qiang Peng, Yong-Jie Yang, Ting Zhang, Cheng-Yu Wu, Qin Yang… in Pharmaceutical Research (2013)

  15. No Access

    Article

    The Preparation and Evaluation of Water-Soluble SKLB610 Nanosuspensions with Improved Bioavailability

    The aim of the study was to investigate the potential of nanosuspension to enhance the bioavailability of SKLB610 (Biopharmaceutical Classification System class II drug), a bioactive anticancer compound synthe...

    Yunchuang Huang, Xun Luo, **nyu You, Yong **a, Xuejiao Song… in AAPS PharmSciTech (2013)

  16. No Access

    Article

    Novel Pyrazoline-Based Selective Fluorescent Sensor for Hg2+

    This paper presents the preparation of a pyrazoline compound and the properties of its UV–Vis absorption and fluorescence emission. Moreover, this compound can be used to determine Hg2+ ion with selectivity and s...

    Sheng-Qing Wang, Shu-Yan Liu, Hao-Yan Wang, **ao-**n Zheng… in Journal of Fluorescence (2014)

  17. No Access

    Article

    Targeted Paclitaxel Delivery to Tumors Using Cleavable PEG-Conjugated Solid Lipid Nanoparticles

    To develop a tumor-targeted drug delivery system based on solid lipid nanoparticles (SLNs) conjugated with the enzymatically cleavable polyethylene glycol (PEG).

    Jie Zheng, Yu Wan, Abdelbary Elhissi, Zhirong Zhang, Xun Sun in Pharmaceutical Research (2014)

  18. No Access

    Article

    Emodin Inhibits Inducible Nitric Oxide Synthase in a Rat Model of Craniocerebral Explosive Injury

    To investigate the effects of emodin on blast-induced traumatic brain injury (bTBI) in a rat model. Eighty rats were randomly divided into 2 groups (the control group and the emodin-treated group; N = 40 per ...

    Yuan Ma, Xun **a, **g-min Cheng, Yong-qin Kuang, Tao Yang… in Neurochemical Research (2014)

  19. No Access

    Article

    Enhancement of Nasal HIV Vaccination with Adenoviral Vector-Based Nanocomplexes Using Mucoadhesive and DC-Targeting Adjuvants

    To investigate the vaccine effect of a replication-defective recombinant adenovirus 5 (rAd5)-based nanocomplex with chitooligosaccharides (Oligo) and mannosylated polyethyleneimine-triethyleneglycol (mPEI) as ...

    Yuhong Jiang, Man Li, Zhirong Zhang, Tao Gong, Xun Sun in Pharmaceutical Research (2014)

  20. No Access

    Article

    Rifampicin Loaded Mannosylated Cationic Nanostructured Lipid Carriers for Alveolar Macrophage-specific Delivery

    In this study, cationic mannosylated nanostructured lipid carriers (Man-NLCs) were developed for the targeted delivery of rifampicin to alveolar macrophages.

    Xu Song, Qing Lin, Ling Guo, Yao Fu, Jianfeng Han, Huan Ke… in Pharmaceutical Research (2015)

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