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Article
Open AccessAssessing the Impact of an Artificial Intelligence-Based Model for Intracranial Aneurysm Detection in CT Angiography on Patient Diagnosis and Outcomes (IDEAL Study)—a protocol for a multicenter, double-blinded randomized controlled trial
This multicenter, double-blinded, randomized controlled trial (RCT) aims to assess the impact of an artificial intelligence (AI)-based model on the efficacy of intracranial aneurysm detection in CT angiography...
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Article
Valorization of bagasse alkali lignin to water-soluble derivatives through chemical modification
Black liquor is the by-product of the pul** process where the lignin, hemicellulose, and extractive materials are separated from wood to produce paper pulp. As one of the primary lignin sources, black liquor...
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Article
Hypoxia-Challenged Pancreatic Adenocarcinoma Cell-Derived Exosomal circR3HCC1L Drives Tumor Growth Via Upregulating PKM2 Through Sequestering miR-873-5p
Pancreatic adenocarcinoma (PAAD) is a fatal disease with poor survival. Increasing evidence show that hypoxia-induced exosomes are associated with cancer progression. Here, we aimed to investigate the function...
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Article
Open AccessSingle-Cell RNA Sequencing Transcriptomics Revealed HCMV IE2-Related Microglia Responses in Alzheimer’s-Like Disease in Transgenic Mice
Although multiple factors are known to concur with Alzheimer’s disease (AD), the relationship between human cytomegalovirus (HCMV) and AD-like disease is unclear. Here, we propose a hypothesis that HCMV im...
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Article
Open AccessKupffer cells dictate hepatic responses to the atherogenic dyslipidemic insult
Apolipoprotein-B (APOB)-containing lipoproteins cause atherosclerosis. Whether the vasculature is the initially responding site or if atherogenic dyslipidemia affects other organs simultaneously is unknown. He...
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Article
Secure Routing Strategy Based on Attribute-Based Trust Access Control in Social-Aware Networks
In social aware networks, the routing protocol possesses a considerable amount of sensitive user information during node transmission. When selecting the next hop node for transmitting information in social se...
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Article
Antimicrobial Peptide MPX with Broad-Spectrum Bactericidal Activity Promotes Proper Abscess Formation and Relieves Skin Inflammation
Bacteria have developed antibiotic resistance during the large-scale use of antibiotics, and multidrug-resistant strains are common. The development of new antibiotics or antibiotic substitutes has become an i...
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Article
Open AccessHuman Cytomegalovirus IE2 Disrupts Neural Progenitor Development and Induces Microcephaly in Transgenic Mouse
Human cytomegalovirus (HCMV) is a significant contributor to congenital birth defects. Limited by the lack of animal models, the pathogenesis of neurological damage in vivo caused by HCMV infection and the rol...
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Article
A Novel Solvent Combined Zinc Chloride and Organic Acid for Highly Efficient and Green Disassembly of Lignocelluloses Toward Lignin Valorization
The effective fractionation of lignocelluloses at mild conditions is essential for extensive valorization of lignin. In the present study, a hybrid solvent combining zinc chloride and lactic acid (ZnCl2/Lac) was ...
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Article
Open AccessGut microbiota induces hepatic steatosis by modulating the T cells balance in high fructose diet mice
Metabolic diseases are often associated with high fructose (HF) consumption. HF has also been found to alter the gut microbiota, which then favors the development of nonalcoholic fatty liver disease. However, ...
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Article
Open AccessIFT140+/K14+ cells function as stem/progenitor cells in salivary glands
Stem/progenitor cells are important for salivary gland development, homeostasis maintenance, and regeneration following injury. Keratin-14+ (K14+) cells have been recognized as bona fide salivary gland stem/proge...
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Article
Reinforcing Paper Strength with High Viscosity Aminated Cellulose Nanocrystal by Forming Nanocrystal Networks
Higher tensile and bursting strength are paramount concerns in paper-based packaging materials. Herein, the aminated cellulose nanocrystal (A-CNC) was synthesized by the amination reactions firstly, and the ba...
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Article
Copper extraction from low-grade chalcopyrite in a bioleaching column assisted by bioelectrochemical system
Low-grade ores, tailings, and solid wastes contain small amounts of valuable heavy metals. Improper disposal of these substances results in the waste of resources and contamination of soil or groundwater. Acco...
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Article
Correction to: Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants
The last author name has been incorrectly published in the original publication. The complete correct name is given below.
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Chapter and Conference Paper
Building a Virtual Simulation Teaching and Learning Platform Towards Creative Thinking for Bei**g Shahe Education Park
In response to China’s innovation-driven development strategy. The course development team is develo** a course on innovation and entrepreneurship education. The course guides students to break through their...
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Article
Molecular characterization of ctDNA from Chinese patients with advanced gastric adenocarcinoma reveals actionable alterations for targeted and immune therapy
Circulating tumor DNA (ctDNA) is considered an ideal sample type for genoty** patients with advanced unresectable cancer to inform treatment decision. It may better capture tumor heterogeneity, especially in...
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Article
Fabrication of Novel Cellulose-Based Antibacterial Film Loaded with Poacic Acid against Staphylococcus Aureus
Aimed at decreasing the environmental pollution caused by petroleum-derived packing materials, many efforts have been directed towards fabricating biodegradable substitutes, especially of cellulose-based film ...
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Article
A kinetic study on the hydrolysis of corncob residues to levulinic acid in the FeCl3–NaCl system
Levulinic acid (LA) production from corncob acid hydrolysis residues (CAHR) using FeCl3 as Lewis acid catalyst in green solutions of salt was investigated. The reaction kinetic relationships were determined in th...
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Article
Aquaporin 5 is degraded by autophagy in diabetic submandibular gland
Autophagy is a catabolic process which is involved in the development of many diseases including diabetes mellitus and its complications. Hyposalivation is a common complication of diabetes mellitus, whereas i...
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Article
Dispersion and Rheological Properties of Aqueous Graphene Suspensions in Presence of Nanocrystalline Cellulose
The possibility and feasibility of nanocrystalline cellulose (NCC) for dispersing hydrophobic graphene in aqueous solutions were studied in the present work. The dispersion properties of graphene particles in ...
