-
Article
Open AccessComparison of efficacy and safety between PD-1 inhibitors and PD-L1 inhibitors plus platinum-etoposide as first-line treatment for extensive-stage small-cell lung cancer: a multicenter, real-world analysis
Immunotherapy in combination with platinum-etoposide (EP) chemotherapy has been approved as a first-line treatment for extensive-stage small cell lung cancer (ES-SCLC). However, real-world (RW) data regarding ...
-
Article
Open AccessPralsetinib-associated pneumonia in RET fusion-positive non-small cell lung cancer
Oncogenic alternation in RET is one of the important targets of non-small cell lung cancer (NSCLC). Pralsetinib has shown great efficacy in RET fusion-positive NSCLC, but a series of adverse reactions will ine...
-
Article
Guaranteed Safe Path and Trajectory Tracking via Reachability Analysis Using Differential Inequalities
In many automated motion planning systems, vehicles are tasked with tracking a reference path or trajectory that is safe by design. However, due to various uncertainties, real vehicles may deviate from such re...
-
Article
Open AccessDNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming
DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. It has been reported that DNMT3A mutation plays a key role in leukemogene...
-
Article
RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines
Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects includin...
-
Article
Open AccessChimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential
Chimeric antigen receptor (CAR)-engineered T (CAR-T) cells have obtained prominent achievement in the clinical immunotherapy of hematological malignant tumors, leading to a rapid development of cellular immuno...
-
Article
Open AccessDrug-related adverse events potentially predict the efficacy of apatinib on advanced hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide every year, and most HCC patients are diagnosed with advanced disease and can only receive systemic treatment. TKIs...
-
Article
Open AccessCorrection to: Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
-
Article
Open AccessTemporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a temporally and spatially specific manner. Here, using single-cell transcriptomic analyses combined with classic anatomica...
-
Article
Open AccessControlling supramolecular filament chirality of hydrogel by co-assembly of enantiomeric aromatic peptides
Supramolecular chirality plays an indispensable role in living and synthetic systems. However, the generation and control of filament chirality in the supramolecular hydrogel of short peptides remains challeng...
-
Chapter and Conference Paper
Research on the Hydrodynamic Calculation of Variable Structure Underwater Vehicle Based on CFD
In order to speed up the construction of ocean intelligence, improving the intelligent operation level of Underwater Vehicles is one of the current research directions. This paper takes the Variable Structure ...
-
Article
Open AccessComprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemogl...
-
Article
β-FeOOH catalyzed peroxymonosulfate for organic pollutant degradation in water: radical and non-radical mechanism
Iron-based catalysts as peroxymonosulfate (PMS) activator are commonly used to oxidize and degrade azo dye. However, there are still some issues such as low catalytic performance, relatively less reactive oxyg...
-
Article
Open AccessEffect of incision on visual outcomes after implantation of a trifocal diffractive IOL
To evaluate visual acuity, corneal astigmatism and corneal higher-order aberrations (HOAs) after implantation of trifocal diffractive IOLs operated with either a corneal steep-axis incision or 135° incision.
-
Article
Y-chromosome polymorphisms of the domestic Bactrian camel in China
Single-nucleotide polymorphisms (SNPs), microsatellites and copy number variation (CNV) were studied on the Y chromosome to understand the paternal origin and phylogenetic relationships for resource protection...
-
Article
Phylogenetic analysis of Tibetan mastiffs based on mitochondrial hypervariable region I
Recently, the number of Tibetan mastiffs, which is a precious germplasm resource and cultural heritage, is decreasing sharply. Therefore, the genetic diversity of Tibetan mastiffs needs to be studied to clarif...
-
Article
Genetic and epigenetic modifications to the BBAA component of common wheat during its evolutionary history at the hexaploid level
The formation and evolution of common wheat (Triticum aestivum L., genome BBAADD) involves allopolyploidization events at two ploidy levels. Whether the two ploidy levels (tetraploidy and hexaploidy) have impacte...
-
Article
Develo** a quantitative landscape regionalization framework integrating driving factors and response attributes of landscapes
Regionalization plays an important role in delineating landscape heterogeneity and providing spatial frameworks for environmental management. In this study, we developed a comprehensive regionalization approac...
-
Article
Cytochrome P450 2A13 is an efficient enzyme in metabolic activation of aflatoxin G1 in human bronchial epithelial cells
Cytochrome P450 2A13 (CYP2A13) is an extrahepatic enzyme that mainly expresses in human respiratory system, and it is reported to mediate the metabolic activation of aflatoxin B1. Due to the structural simila...
-
Article
Temporal variation of characteristic scales in urban landscapes: an insight into the evolving internal structures of China’s two largest cities
Urbanization has induced profound landscape changes. While the spatiotemporal patterns of urban landscapes have been extensively studied, the manner by which the internal structures of already urbanized areas ...
