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Article
Open AccessCopy number alteration features in pan-cancer homologous recombination deficiency prediction and biology
Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose po...
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Article
Open AccessExtrachromosomal DNA formation enables tumor immune escape potentially through regulating antigen presentation gene expression
Extrachromosomal DNA (ecDNA) is a type of circular and tumor specific genetic element. EcDNA has been reported to display open chromatin structure, facilitate oncogene amplification and genetic material unequa...
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Article
Improving thermal shock and ablation resistance of high thermal conductivity carbon/carbon composites by introducing carbon nanotubes
In order to improve the thermal shock and ablation resistance of high thermal conductivity carbon/carbon composites, carbon nanotubes (CNTs) were introduced by electrophoretic deposition. After modification, t...
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Article
Open AccessOsZIP1 functions as a metal efflux transporter limiting excess zinc, copper and cadmium accumulation in rice
Metal homeostasis is critical for plant growth, development and adaptation to environmental stresses and largely governed by a variety of metal transporters. The plant ZIP (Zn-regulated transporter, Iron-regulate...
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Article
Open AccessAPOBEC3B and APOBEC mutational signature as potential predictive markers for immunotherapy response in non-small cell lung cancer
Non-small cell lung cancer (NSCLC) is known to carry heavy mutation load. Besides smoking, cytidine deaminase APOBEC3B plays a key role in the mutation process of NSCLC. APOBEC3B is also reported to be upregul...
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Article
Open AccessAuthor Correction: Expression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer
Lipids, either endogenously synthesized or exogenous, have been linked to human cancer. Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer (CaP). We demonstrated that co...
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Article
Open AccessExpression of both poly r(C) binding protein 1 (PCBP1) and miRNA-3978 is suppressed in peritoneal gastric cancer metastasis
The expression of legumain which has been shown overexpressed in patients with metastatic gastric cancer is positively correlated to both disease progression and outcome, and negatively correlated to microRNA ...
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Article
Fatigue Behavior of Dissimilar Al–Mg–Si/Al–Zn–Mg Aluminum Alloys Friction Stir Welding Joints
In this study, fatigue properties and fracture mechanism of dissimilar Al–Mg–Si/Al–Zn–Mg aluminum alloys friction stir welding (FSW) joints were investigated and the effect of the sheet configuration on the fa...
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Article
Open AccessLRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair
Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unex...
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Article
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
The transcription factor Zbtb7a was previously described as an oncogene in non-Hodgkin lymphoma. Now, Pier Paolo Pandolfi and colleagues report that loss of Zbtb7a accelerates the progression of invasive prostate...
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Article
Intracranial extraaxial ependymoma in children: a rare case report and review of the literature
Intracranial extraaxial ependymomas (IEAEs) are extremely rare. We present a pediatric patient with IEAE misdiagnosed as a meningioma preoperatively, successfully treated surgically with a favorite outcome. Th...
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Article
Numerical simulation of weld tab length influence on welding residual stress and distortion of aero-engine disk
In order to control the welding residual stress and distortion to the greatest extent, based on the MSC. MARC software platform and adopting the impending critical value methods gradually, the welding residual...
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Article
Welding distortion control of automobile engine stator by finite element method
In this paper, a thermal elastic-plastic finite element method (FEM) is used to simulate the plasma welding process in order to predict the welding distortion of automobile stator iron core. Six spatial symmet...
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Article
Thermal Stable Pd/Ce0.2Y0.8O2-δ Catalysts for CO and CH4 Oxidation
A series of Pd/Ce0.2Y0.8O2-δ catalysts were prepared and tested for CO and CH4 oxidation. It is found that the Pd/Ce0.2Y0.8O2-δ catalysts are thermal stable, and the catalytic activity enhances with increasing ca...
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Article
Discussion and calculation on welding residual longitudinal stress and plastic strain by finite element method
In recent years, some researchers have put forward the new viewpoint that the weld is merely formed during the cooling process, not concerned with the heating process. According to this view, it can be conclud...
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Article
Rig-I−/− mice develop colitis associated with downregulation of Gαi2
RIG-I (retinoid acid-inducible gene-I), a putative RNA helicase with a cytoplasmic caspase-recruitment domain (CARD), was identified as a pattern-recognition receptor (PRR) that mediates antiviral immunity by ...
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Article
Expression of TRAIL and TRAIL receptors in normal and malignant tissues
TRAIL, tumor necrosis factor-related apoptosis-inducing ligand, is a member of the TNF family of proteins. Tumour cells were initially found to have increased sensitivity to TRAIL compared with normal cells, r...
