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Article
Empagliflozin ameliorates vascular calcification in diabetic mice through inhibiting Bhlhe40-dependent NLRP3 inflammasome activation
Type 2 diabetes mellitus (T2DM) patients exhibit greater susceptibility to vascular calcification (VC), which has a higher risk of death and disability. However, there is no specific drug for VC therapy. NLRP3...
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Article
A Facile Probe for Fluorescence Turn-on and Simultaneous Naked-Eyes Discrimination of H2S and biothiols (Cys and GSH) and Its Application
Hydrogen sulfide and biothiol molecules such as Cys and GSH acted important roles in many physiological processes. To simultaneously detect and distinguish them was quite necessary by a suitable fluorescent pr...
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Article
Open AccessPDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming
Pyruvate dehydrogenase kinase 4 (PDK4) is an important mitochondrial matrix enzyme in cellular energy regulation. Previous studies suggested that PDK4 is increased in the calcified vessels of patients with ath...
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Article
Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy
Arterial media calcification is related to mitochondrial dysfunction. Protective mitophagy delays the progression of vascular calcification. We previously reported that lactate accelerates osteoblastic phenoty...
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Article
Arginine Vasopressin-Aquaporin-2 Pathway-Mediated Dehydration Effects of Electroacupuncture in Guinea Pig Model of AVP-Induced Eendolymphatic Hydrops
To investigate the effects of electroacupuncture (EA) on endolymphatic hydrops (EH) and the regulation of arginine vasopressin (AVP)-aquaporin-2 (AQP2) pathway in guinea pigs.
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Article
A quinoline-based Schiff base for significant fluorescent “turn-on” and absorbance-ratiometric detection of Al3+
A novel quinoline-based Schiff base fluorescent sensor BQPA had been synthesized and characterized by common spectroscopic methods. It showed highly sensitive fluorescent enhancement (300-fold) and ratiometric...
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Article
A Highly Selective Fluorescence “Turn on” and Absorbance-Ratiometric Detection of Al3+ in Totally H2O and its Application in Test Paper
A novel naphthalene based fluorescence probe NBDH was designed and synthesized. Probe NBDH exhibited highly selective and sensitive responses towards Al3+ in HEPES-NaOH buffer solution (pH = 7.4). In addition, th...
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Article
Open AccessFructus Ligustri Lucidi modulates estrogen receptor expression with no uterotrophic effect in ovariectomized rats
Accumulating evidence suggests that Fructus Ligustri Lucidi (FLL) plays a beneficial role in preventing the development of osteoporosis. However, the effects of FLL on estrogen receptor (ER) α and ERβ expressions...
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Article
A Highly Selective Naphthalimide-Based Chemosensor: “Naked-Eye” Colorimetric and Fluorescent Turn-On Recognition of Al3+ and Its Application in Practical Samples, Test Paper and Logic Gate
A novel naphthalimide-based colorimetric and fluorescent turn-on chemosensor for Al3+ was synthesized and characterized with spectroscopic techniques. In MeOH solution, BPAM showed high selectivity and sensitivit...
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Article
Ultrafine grain effect on pearlitic transformation in hypereutectoid steel
Pearlitic transformation in an ultrafine-grained (UFG) hypereutectoid steel was investigated. The steel was a plain carbon steel containing 1.0 wt% C and very few other elements. The UFG samples were prepared ...
