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Article
Open AccessAssociations between sleep quality and co** style among front-line nurses: a cross-sectional study in China
Good sleep is crucial for healthcare professionals, especially nurses, to prevent errors and injuries that may occur during caregiving. This study investigated the sleep quality and co** styles of nurses dur...
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Article
Open AccessmRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy
Synergistically improving T-cell responsiveness is promising for favorable therapeutic outcomes in immunologically cold tumors, yet current treatments often fail to induce a cascade of cancer-immunity cycle fo...
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Article
Open AccessDiscovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a primary cause of cirrhosis and hepatocellular carcinoma. Unfortunately, there is no approved drug treatment for NASH. AMP-activated kinase (AMPK) is an important metab...
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Article
Open AccessDiscovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus
Natural products are well established as an important resource and play an important role in drug discovery. Here, two pyrrolinone-fused benzoazepine alkaloids, (+)-asperazepanones A (1) and B (2) with a 6/7/5 ri...
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Article
Preparation, Structure Elucidation, and Cytotoxic Activity of Amide Derivatives of Hydroxysydonic Acid
Hydroxysydonic acid (1), a naturally abundant bisabolane sesquiterpenoid metabolite, has been obtained from the endophytic fungus Aspergillus versicolor isolated from Elaeocarpus decipiens Hemsl. To increase its ...
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Article
Evaluation of Vestibular Function in Diagnosis of Vestibular Schwannomas
Vestibular schwannomas (VS) are benign tumors of the vestibular nerve. The common first symptoms are hearing loss and tinnitus, followed by imbalance, vertigo, and facial nerve involvement. The subjective symp...
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Article
Open AccessInvestigating causal relationships between exposome and human longevity: a Mendelian randomization analysis
Environmental factors are associated with human longevity, but their specificity and causality remain mostly unclear. By integrating the innovative “exposome” concept developed in the field of environmental ep...
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Article
Secondary Metabolites from the Endophytic Fungus Xylariales sp. and their Antimicrobial Activity
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Article
Open AccessSurvival benefit of re-irradiation in esophageal Cancer patients with Locoregional recurrence: a propensity score-matched analysis
To investigate the treatment failure pattern and factors influencing locoregional recurrence of esophageal squamous cell carcinoma (ESCC) and examine patient survival with re-irradiation (re-RT) after primary ...
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Article
Open AccessDiscovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives
Ten antifouling 14-membered resorcylic acid lactones 1–10 were isolated previously with low or trace natural abundance from the zoanthid-derived Cochliobolus lunatus fungus. Further optimization of fermentation c...
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Article
Preparation, Structure Elucidation, and Antiviral and Cytotoxic Activities of Acylation Derivatives of Cytochalasin B
Five acylation derivatives (1a–1e) were prepared by acylation of cytochalasin B (1), which was isolated from the marine-derived fungus Curvularia lunata. Compound 1 and its acylation derivatives 1a–1e were evalua...
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Article
Open AccessLong noncoding RNA lnc-RI is a new regulator of mitosis via targeting miRNA-210-3p to release PLK1 mRNA activity
Increasing evidence indicates that lncRNAs play critical roles in various biological processes, but many have not been functionally characterized. Here, we report a novel radiation-inducible lncRNA, namely lnc...
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Article
Effects of added polyacrylamide on changes in water states during the composting of kitchen waste
The effects of adding polyacrylamide (PAM), to attempt to delay the loss of capillary water and achieve a better level of organic matter humification, in the composting of kitchen waste were evaluated. Four tr...
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Article
Changes in texture and retorting yield in oil shale during its bioleaching by Bacillus Mucilaginosus
Bioleaching of oil shale by Bacillus mucilaginosus was carried out in a reaction column for 13 d. The pH value of the leaching liquor decreased steadily from 7.5 to 5.5 and the free silicon dioxide concentration ...
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Article
Numerical study of water age influenced by tide and runoff in Daliaohe Estuary in China
Based on the concept of the age, the water transport characteristics as the response to the runoff and the tide in Daliaohe Estuary in China are studied under different hydrodynamic conditions using a three-di...
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Article
Open AccessHigh prevalence of plasmid-mediated 16S rRNA methylase gene rmtB among Escherichia coliclinical isolates from a Chinese teaching hospital
Recently, production of 16S rRNA methylases by Gram-negative bacilli has emerged as a novel mechanism for high-level resistance to aminoglycosides by these organisms in a variety of geographic locations. There...
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Article
Open AccessMolecular characterization of Staphylococcus aureus isolates causing skin and soft tissue infections (SSTIs)
Staphylococcus aureus, particularly methicillin-resistant S. aureus (MRSA), is an important cause of pyogenic skin and soft tissue infections (SSTIs). The aim of present study is to investigate the molecular cha...
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Article
Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma
Anti-tumor vaccines capable of activating both CD4 and CD8 T cells are preferred for long lasting T cell responses. Induction of a tumor-specific T-cell response can be induced by tumor vaccines that target in...
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Article
Seventeen-year follow-up study on chromosomal aberrations in five victims accidentally exposed to several Gy of 60Co γ-rays
On 25 June 1990, a radiation accident occurred in a 60Co source radiation unit in Shanghai, due to violations in operation regulations. This accident resulted in the exposure of seven individuals to acute high-do...
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Article
Production of bacterial blight resistant lines from somatic hybridization between Oryza sativa L. and Oryza meyeriana L.
Novel bacterial blight (BB) resistance gene(s) for rice was (were) introduced into a cultivated japonica rice variety Oryza sativa (cv. 8411), via somatic hybridization using the wild rice Oryza meyeriana as the ...
