-
Article
Distinctly altered lipid components in hepatocellular carcinoma relate to impaired T cell-dependent antitumor immunity
T cells are master effectors of anti-tumor immunity in cancer. Recent studies suggest that altered lipid metabolism imposed by the tumor microenvironment constrains anti-tumor immunity. However, the tumor-asso...
-
Article
Revealing a Novel Methylated Integrin Alpha-8 Related to Extracellular Matrix and Anoikis Resistance Using Proteomic Analysis in the Immune Microenvironment of Lung Adenocarcinoma
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes associated with ECM and constructed immune...
-
Article
METTL3 Mediates Microglial Activation and Blood–Brain Barrier Permeability in Cerebral Ischemic Stroke by Regulating NLRP3 Inflammasomes Through m6A Methylation Modification
Cerebral ischemic stroke (CIS) is the main cause of disability. METTL3 is implicated in CIS, and we explored its specific mechanism. Middle cerebral artery occlusion (MCAO) rat model and oxygen–glucose depriva...
-
Article
Open AccessShuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo
Gene editing strategies for cystic fibrosis are challenged by the complex barrier properties of airway epithelia. We previously reported that the amphiphilic S10 shuttle peptide non-covalently combined with CR...
-
Article
Open AccessGenome-wide association study exploring the genetic architecture of eggshell speckles in laying hens
Eggshell speckle phenotype is an important trait in poultry production because they affect eggshell quality. However, the genetic architecture of speckled eggshells remains unclear. In this study, we determine...
-
Article
Comparison of data-driven identified hypertension-protective dietary patterns among Chinese adults: based on a nationwide study
Diet pattern (DP) is a key modifiable and cost-effective factor in hypertension (HTN) management. The current study aimed to identify and compare the hypertension-protective DPs among Chinese adults.
-
Article
Analysis of Emerging Contaminants in Surface Water, Aquaculture Ponds and Wastewater Treatment Facilities in the Taige Canal Basin
Emerging contaminants(ECs) have aroused great concerns due to their widespread presence as well as their potential health and ecological risks. Currently monitoring data about ECs in Chinese rural areas are st...
-
Article
Open AccessIdentification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study
Eggs represent important sources of protein and are widely loved by consumers. Egg yolk taste is an important index for egg selection, and the moisture content of the egg yolk affects the taste. To understand ...
-
Article
Dihydromyricetin inhibits Hepatitis B virus replication by activating NF-κB, MAPKs, and autophagy in HepG2.2.15 cells
Hepatitis B virus (HBV) infection is a severe global health problem, and there has been no effective method to eliminate HBV. This study was designed to explore the pharmacological mechanism of Dihydromyriceti...
-
Article
Open AccessDNA methylome and transcriptome identified Key genes and pathways involved in Speckled Eggshell formation in aged laying hens
The quality of poultry eggshells is closely related to the profitability of egg production. Eggshell speckles reflect an important quality trait that influences egg appearance and customer preference. However,...
-
Article
Cloning and expression of recombinant human superoxide dismutase 1 (hSOD1) in Bacillus subtilis 1012
We aimed to clone and express the human Cu, Zn superoxide dismutase (hSOD1) in Bacillus subtilis 1012. Also, we investigated the expression level of hSOD1 under different induction conditions.
-
Article
Open AccessZebrafish: an efficient vertebrate model for understanding role of gut microbiota
Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and genetically tractable vertebrate model, zebrafish have been widely used for biological research. Zebrafish and humans s...
-
Article
Drought analysis during the growth stages of grape in the main grape-growing regions in China
In China, grape is one of the top five fruit crops for both bearing acreage and production. Recently, national grape production has been stalling because of an increase in drought events. In order to combat th...
-
Article
Exosomes derived from mesenchymal stem cells regulate Treg/Th17 balance in aplastic anemia by transferring miR-23a-3p
Imbalanced Th17/Treg ratio is implicated in the pathogenesis of aplastic anemia. Studies have indicated that bone marrow-derived mesenchymal stem cells-derived exosomes (BMSC-Exo) could correct imbalanced Th17...
-
Article
Open AccessRole of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy
The hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.
-
Article
Giant enhancement of photoluminescence quantum yield in 2D perovskite thin microplates by graphene encapsulation
The optoelectronic performances of the layered materials are strongly dependent on the thickness of the samples due to the surface effect. As the size of the samples decreases to few nanometers, the surface de...
-
Article
Coupling effect of the conductivities of Li ions and electrons by introducing LLTO@C fibers in the LiNi0.8Co0.15Al0.05O2 cathode
To probe the coupling effect of the electron and Li ion conductivities in Ni-rich layered materials (LiNi0.8Co0.15Al0.05O2, NCA), lithium lanthanum titanate (LLTO) nanofiber and carbon-coated LLTO fiber (LLTO@C) ...
-
Protocol
The Expansion and Cytotoxicity Detection of Human iNKT Cells
Invariant natural killer T (iNKT) cell is a type of innate-like T cell subsets with both T and NK cell phenotype and functions. They recognize lipid antigens presented by CD1d molecules and can be specifically...
-
Chapter and Conference Paper
Carrier Robust Reversible Watermark Model Based on Image Block Chain Authentication
Digital watermarking technology protects information security from the dimension of the existence of hidden information. At present, most watermarking algorithms only focus on the embedding and extraction of s...
-
Article
Open AccessHigh expression of fibroblast activation protein (FAP) predicts poor outcome in high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSOC) is a fatal form of ovarian cancer. Previous studies indicated some potential biomarkers for clinical evaluation of HGSOC prognosis. However, there is a lack of systemat...
