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  1. Article

    Open Access

    Artesunate treats obesity in male mice and non-human primates through GDF15/GFRAL signalling axis

    Obesity, a global health challenge, is a major risk factor for multiple life-threatening diseases, including diabetes, fatty liver, and cancer. There is an ongoing need to identify safe and tolerable therapeut...

    Xuanming Guo, Pallavi Asthana, Lixiang Zhai, Ka Wing Cheng… in Nature Communications (2024)

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  2. Article

    Open Access

    Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2. The full-length membrane form of ACE2 (mem...

    Xuanming Guo, Jianli Cao, Jian-Piao Cai, Jiayan Wu, Jiangang Huang… in Nature Communications (2022)

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  3. Article

    Open Access

    Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor

    Insulin sensitivity progressively declines with age. Currently, the mechanism underlying age-associated insulin resistance remains unknown. Here, we identify membrane-bound matrix metalloproteinase 14 (MT1-MMP...

    Xuanming Guo, Pallavi Asthana, Susma Gurung, Shuo Zhang… in Nature Communications (2022)

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  4. No Access

    Article

    Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

    GDNF-family receptor a-like (GFRAL) has been identified as the cognate receptor of growth/differentiation factor 15 (GDF15/MIC-1), considered a key signaling axis in energy homeostasis and body weight regulati...

    Chi Fung Willis Chow, Xuanming Guo, Pallavi Asthana, Shuo Zhang… in Nature Metabolism (2022)