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    Article

    Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics

    Most biotherapeutics can elicit immune responses in dosed recipients generating anti-drug antibodies (ADAs). Neutralizing antibodies (NAbs) are a subpopulation of ADAs that can potentially impact patient safet...

    Bonnie Wu, Shan Chung, Xu-Rong Jiang, Jim McNally… in The AAPS Journal (2016)

  2. Article

    A Neutralizing Antibody Assay Based on a Reporter of Antibody-Dependent Cell-Mediated Cytotoxicity

    Benralizumab is a humanized anti-IL5 receptor α (IL5Rα) monoclonal antibody (mAb) with enhanced (afucosylation) antibody-dependent cell-mediated cytotoxicity (ADCC) function. An ADCC reporter cell-based neutra...

    Yuling Wu, Jia J. Li, Hyun Jun Kim, Xu Liu, Weiyi Liu, Ahmad Akhgar… in The AAPS Journal (2015)

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    Article

    Advances in the assessment and control of the effector functions of therapeutic antibodies

    The Fc (crystallizable fragment) region of therapeutic antibodies can have an important role in their safety and efficacy. This article summarizes the current knowledge of antibody Fc functionality, provides a...

    Xu-Rong Jiang, An Song, Svetlana Bergelson, Thomas Arroll… in Nature Reviews Drug Discovery (2011)