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  1. Article

    Open Access

    Characterization of IgG1 Fc Deamidation at Asparagine 325 and Its Impact on Antibody-dependent Cell-mediated Cytotoxicity and FcγRIIIa Binding

    Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important mechanism of action for many therapeutic antibodies. A therapeutic immunoglobulin (Ig) G1 monoclonal antibody lost more than half of its ADCC a...

    **aojun Lu, Lee Ann Machiesky, Niluka De Mel, Qun Du, Weichen Xu… in Scientific Reports (2020)

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  2. No Access

    Chapter

    Biological Activity Assays for Antibody Therapeutics

    The measurement of biological activity is required for therapeutic antibodies at release of a new manufacturing batch and throughout the product life cycle. However, the applicable regulatory guidelines provid...

    Xu-Rong Jiang, Anthony Mire-Sluis in Biosimilars (2018)

  3. No Access

    Article

    Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics

    Most biotherapeutics can elicit immune responses in dosed recipients generating anti-drug antibodies (ADAs). Neutralizing antibodies (NAbs) are a subpopulation of ADAs that can potentially impact patient safet...

    Bonnie Wu, Shan Chung, Xu-Rong Jiang, Jim McNally… in The AAPS Journal (2016)

  4. Article

    A Neutralizing Antibody Assay Based on a Reporter of Antibody-Dependent Cell-Mediated Cytotoxicity

    Benralizumab is a humanized anti-IL5 receptor α (IL5Rα) monoclonal antibody (mAb) with enhanced (afucosylation) antibody-dependent cell-mediated cytotoxicity (ADCC) function. An ADCC reporter cell-based neutra...

    Yuling Wu, Jia J. Li, Hyun Jun Kim, Xu Liu, Weiyi Liu, Ahmad Akhgar… in The AAPS Journal (2015)

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  5. No Access

    Article

    Advances in the assessment and control of the effector functions of therapeutic antibodies

    The Fc (crystallizable fragment) region of therapeutic antibodies can have an important role in their safety and efficacy. This article summarizes the current knowledge of antibody Fc functionality, provides a...

    Xu-Rong Jiang, An Song, Svetlana Bergelson, Thomas Arroll… in Nature Reviews Drug Discovery (2011)

  6. No Access

    Article

    Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

    Expression of the human telomerase catalytic component, hTERT, in normal human somatic cells can reconstitute telomerase activity and extend their replicative lifespan1,2. We report here that at twice the normal ...

    Xu-Rong Jiang, Gretchen Jimenez, Edwin Chang, Maria Frolkis… in Nature Genetics (1999)

  7. No Access

    Article

    Effect of low oxygen and high carbon dioxide on the levels of ethylene and 1-aminocyclopropane-1-carboxylic acid in ripening apple fruits

    The association of the level of ACC and the ethylene concentration in ripening apple fruit (Malus sylvestris Mill, var. Ben Davis) was studied. Preclimacteric apple contained small amounts of ACC and ethylene. Wi...

    Li Zhen-guo, Liu Yu, Dong Jian-guo, Xu Rong-jiang… in Journal of Plant Growth Regulation (1983)