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  1. Article

    Open Access

    Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway

    The Helicobacter pylori vacuolating cytotoxin (VacA) can promote progressive vacuolation and gastric injury and may be associated with human gastric cancer. Increasing evidence indicates that autophagy is involve...

    Pan Zhu, Jun Xue, Zhu-jun Zhang, Yin-** Jia, Ya-nan Tong, Dan Han… in Cell Death & Disease (2017)

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  2. No Access

    Article

    Increased intratumoral IL-22-producing CD4+ T cells and Th22 cells correlate with gastric cancer progression and predict poor patient survival

    IL-22-producing CD4+ T cells (IL-22+CD4+ T cells) and Th22 cells (IL-22+IL-17−IFN-γ−CD4+ T cells) represent newly discovered T-cell subsets, but their nature, regulation, and clinical relevance in gastric cancer ...

    Yuan Zhuang, Liu-sheng Peng, Yong-liang Zhao, Yun Shi… in Cancer Immunology, Immunotherapy (2012)

  3. No Access

    Article

    Increased tumor-infiltrating CD8+Foxp3+ T lymphocytes are associated with tumor progression in human gastric cancer

    CD8+Foxp3+ T lymphocytes have been detected in tumors. However, the distribution, phenotypic features, and regulation of these cells in gastric cancer remain unknown.

    Liu-sheng Peng, Yuan Zhuang, Yun Shi, Yong-liang Zhao… in Cancer Immunology, Immunotherapy (2012)

  4. No Access

    Article

    Helicobacter pylori HP0876 is Dispensable for Heme–Iron Acquisition but Attenuates Bacterial Adherence to Gastric Epithelial Cells

    Helicobacter pylori can efficiently capture iron either from free heme or heme-containing compounds in the iron-limited gastric mucosa. However, the heme iron utilization systems of H. pylori hav...

    Tao Liu, Yun Shi, **ao-fei Liu, Ying Guo, Xu-hu Mao, Che Tan… in Current Microbiology (2012)

  5. Article

    Open Access

    Role of gamma-delta T cells in host response against Staphylococcus aureus-induced pneumonia

    Staphylococcus aureus is the major cause of hospital-acquired and community-acquired pneumonia. Host defense to S.aureus infection is largely mediated by the innate immune system. γδ T cells play an important rol...

    ** Cheng, Tao Liu, Wei-Ying Zhou, Yuan Zhuang, Liu-sheng Peng… in BMC Immunology (2012)

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  6. No Access

    Article

    H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells

    MicroRNAs have been implicated as a central regulator of the immune system. We have previously reported that Helicobacter pylori (H. pylori) was able to increase the expression of miR-146a, and miR-146a may negat...

    Na Li, **ang Xu, Bin **ao, En-Dong Zhu, Bo-sheng Li, Zhen Liu… in Molecular Biology Reports (2012)

  7. No Access

    Article

    Protection against Helicobacter pylori infection by a trivalent fusion vaccine based on a fragment of urease B-UreB414

    A multivalent fusion vaccine is a promising option for protection against Helicobacter pylori infection. In this study, UreB414 was identified as an antigenic fragment of urease B subunit (UreB) and it induced an...

    Li Wang, **ao-Fei Liu, Shi Yun, **ao-Peng Yuan, Xu-Hu Mao… in The Journal of Microbiology (2010)

  8. No Access

    Article

    Screening and identification of natural antisense transcripts in Helicobacter pylori by a novel approach based on RNase I protection assay

    Natural antisense transcripts (NATs) are endogenous RNA molecules that exhibit partial or complete complementarity to other RNAs. Studies have shown that NATs may participate in a broad range of gene regulator...

    Bin **ao, Wei Li, Gang Guo, Bo-Sheng Li, Zhen Liu, Bin Tang… in Molecular Biology Reports (2009)

  9. Article

    Fusion expression and immunogenicity of EHEC EspA-Stx2Al protein: Implications for the vaccine development

    Shiga toxin 2 (Stx2) is a major virulence factor for enterohemorrhagic Escherichia coli (EHEC), which is encoded by λ lysogenic phage integrated into EHEC chromosome. Stx2Al, Al subunit of Stx2 toxin has gathered...

    Yan Cheng, Youjun Feng, ** Luo, Jiang Gu, Shu Yu… in The Journal of Microbiology (2009)

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  10. No Access

    Article

    RGD-IL-24, A Novel Tumor-Targeted Fusion Cytokine: Expression, Purification and Functional Evaluation

    Targeting drugs to tumor cells is a central challenge for improving existing cancer therapies. ACDCRGDCFCG peptide (RGD-4C) binds to αvβ3 integrin, which is selectively expressed in tumor blood vessels and on ...

    Bin **ao, Wei Li, Jun Yang, Gang Guo, Xu-Hu Mao, Quan-Ming Zou in Molecular Biotechnology (2009)

  11. No Access

    Article

    Proteomic Insights into Helicobacter pylori Coccoid Forms Under Oxidative Stress

    Helicobacter pylori, an etiological agent of gastroduodenal diseases, undergoes drastic morphological transition from spiral shape to coccoid form under oxidative stress. However, the kno...

    Hao Zeng, Gang Guo, Xu Hu Mao, Wen De Tong, Quan Ming Zou in Current Microbiology (2008)