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  1. Article

    Open Access

    Phase 1 study of oral selective estrogen receptor degrader (SERD) amcenestrant (SAR439859), in Japanese women with ER-positive and HER2-negative advanced breast cancer (AMEERA-2)

    This AMEERA-2 study evaluated the pharmacokinetics, efficacy, and safety of the oral selective estrogen receptor degrader amcenestrant as a monotherapy with dose escalation in Japanese postmenopausal women wit...

    Kenji Tamura, Toru Mukohara, Kan Yonemori, Yumiko Kawabata, Xavier Nicolas… in Breast Cancer (2023)

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  2. Article

    Interaction of a droplet spray with a turbulent plane air jet impacting a wall

    Experiments are carried out to study the interaction of a spray of spherical micronic oil droplets with a turbulent plane air jet impacting a wall. The context is the separation of a contaminated atmosphere wi...

    Syphax Ikardouchene, Stéphane Delaby, Xavier Nicolas in Experiments in Fluids (2023)

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  3. No Access

    Chapter and Conference Paper

    Large Eddy Simulation of Turbulent Heat Transfer in Pipe Flows of Temperature Dependent Power-Law Fluids

    Heat transfer in turbulent forced convection of power-law fluids, in a heated horizontal pipe at isoflux conditions, is analyzed by large eddy simulations (LES), with an extended Smagorinsky model. A temperatu...

    Paulin Sourou Ganmbode, Meryem Ould-Rouiss, Xavier Nicolas… in Turbulence and Interactions (2021)

  4. No Access

    Chapter and Conference Paper

    Experiments and Large Eddy Simulations on Particle Interaction with a Turbulent Air Jet Impacting a Wall

    Experiments and large eddy simulations are carried out to study the interaction of spherical particles with a turbulent air jet impacting a wall. The context is that of the dynamical air curtains used to separ...

    Syphax Ikardouchene, Xavier Nicolas, Stéphane Delaby… in Turbulence and Interactions (2021)

  5. No Access

    Chapter and Conference Paper

    Reference Solutions and URANS Model Characterization for Turbulent Forced Convection Around Heated Square Cylinders

    Reference solutions for the turbulent forced convection of air around heated square cylinders at high Reynolds numbers ( \(Re\ge 10^4\) ...

    Xavier Nicolas, Hua Sun, Yannick Sommerer in Turbulence and Interactions (2021)

  6. Article

    Open Access

    Population Pharmacokinetic/Pharmacodynamic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using an Indirect Response Model to Predict Low-Density Lipoprotein Cholesterol Lowering: Support for a Biologics License Application Submission: Part II

    Alirocumab, a human monoclonal antibody against proprotein convertase subtilisin/kexin type 9 (PCSK9), significantly lowers low-density lipoprotein cholesterol levels.

    Xavier Nicolas, Nassim Djebli, Clémence Rauch, Aurélie Brunet… in Clinical Pharmacokinetics (2019)

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  7. No Access

    Article

    Boiling in Porous Media: Model and Simulations

    We present a modelization of the heat and mass transfers within a porous medium, which takes into account phase transitions. Classical equations are derived for the mass conservation equation, whereas the equa...

    Johann Bénard, Robert Eymard, Xavier Nicolas, Clément Chavant in Transport in Porous Media (2005)