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Article
Brain distribution and metabolic profiling of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats investigated by UHPLC-HRMS/MS following peripheral administration
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is known to be a tobacco-specific N-nitrosamine and has peripheral carcinogenic properties. It can also induce oxidative stress, glial cell activation, and neu...
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Article
Open AccessConversion surgery for advanced hepatocellular carcinoma after combination treatment of lenvatinib and camrelizumab: a case report
Hepatocellular carcinoma (HCC) is an aggressive malignancy with high morbidity and mortality. Conversion therapy can improve surgical resection rate and prolong survival time for patients with advanced HCC. We...
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Chapter and Conference Paper
A Rotary-Cage Valve (RCV) for Variable Damper in Prosthetic Knee
The hydraulic microprocessor-controlled prosthetic knee is a widely used replacement for the human knee. As a typical damper component, the rotary-cage valve (RCV) can effectively decouple the pressure differe...
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Chapter and Conference Paper
Comprehensive Risk Evaluation of International Wind Farm Project in Intertidal Area Under EPC Mode Based on Matter-Element Extension Theory
Owing to the change of concept of energy industry development and the corresponding regional preferential policies in recent years, the renewable energy market with huge potential provides an incredible opport...
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Article
Open AccessUntargeted metabolomics reveals the effect of lovastatin on steroid-induced necrosis of the femoral head in rabbits
Lovastatin is an important medicine and it shows a significant effect against glucocorticoid-induced necrosis of the femoral head. This study aimed to investigate the effect of lovastatin on preventing necrosi...
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Chapter and Conference Paper
Machine Learning Agricultural Application Based on the Secure Edge Computing Platform
Machine learning (ML) is fast becoming a powerful tool for increasing agricultural production, for instance, ML predicts weather and yield through satellite images. Such approaches, however, most applications ...
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Chapter and Conference Paper
Key Location Discovery of Underground Personnel Trajectory Based on Edge Computing
With the rapid development of smart mines, workers’ trajectories can be accurately tracked and generate massive positioning data. However, how to quickly find useful information in a large amount of data is an...
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Article
4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury
To investigate the effect of 4-phenylbutyric acid (4-PBA) on intermittent hypoxia (IH)-induced liver cell injury and to clarify the underlying mechanisms.
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Article
The effects of thermal field on radius of curvature interferometric testing
In high accuracy radius of curvature (ROC) measurement, discrepancy may exist in results on the same optical surface under different temperature. In this paper, the effects of temperature on ROC are analyzed s...
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Article
Unexpected E-stereoselective reductive A3-coupling reaction of terminal alkynes with aldehydes and amines
The transition-metal catalysed three-component coupling of an alkyne, an aldehyde and an amine has been became a widely used method for preparing propargylic amines. Here, we report an unexpected copper(I)-cat...
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Article
Effects of oxidized low density lipoprotein on the expression and function of ABCA1 in macrophages
In the present study, we examined the regulation of the expression and function of ABCA1 by modified LDL (ox-LDL)in vitro. After incubation with apoA-I for 24 h, RAW264. 7 cells effluxed 37.65% cholesterol loaded...
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Article
β-VLDL induced VLDL-R’s up-regulation via PKC-ERK1/2 signal pathway
To explore the intracellular signal pathways for β-VLDL induced very low density lipoprotein receptor (VLDL-R) transcription up-regulation and their effects on lipid accumulation in macrophages, Western Blot w...
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Article
Treatment of menopausal syndrome by acupuncture: A report of 38 cases
To observe the acupuncture treatment of 38 patients with menopausal syndrome. The main acupoints were Fengchi (GB 20), Taiyang (Ex-HN5), Hegu (LI 4), Neiguan (PC 6), Qihai (CV 6), Yanglingquan (GB 34), Taichon...
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Article
Preparation and characterization of polyclonal antibodies against VLDL receptor
The polyclonal antibodies against VLDL receptor were prepared and identified. Rabbits were immunized with polypeptide fragment of VLDL receptor as antigen. The collected blood serum of the immunized rabbits wa...
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Article
Role of VLDL receptor in the process of foam cell formation
The role of very low density lipoprotein receptor (LVLDR) in the process of foam cell formation was investigated. After the primary cultured mouse peritoneal macrophages were incubated with VLDL, β-VLDL or low...
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Article
Induction of very low density lipoprotein receptor (VLDLR) transcription by VLDL is mediated by the extracellular signal-regulated kinase signaling pathway
To elucidate the intracellular signaling pathways for VLDL-induced VLDLR transcription, Western blot analysis was used to examine phosphorylated ERK1/2 protein. It was found that that VLDL induced an increase ...
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Article
Scale-dependent representations of relief based on wavelet analysis
Automatic generalization of geographic information is the core of multi-scale representation of spatial data, but the scale-dependent generalization methods are far from abundant because of its extreme complic...
