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  1. No Access

    Article

    3D bioengineered neural tissue generated from patient-derived iPSCs mimics time-dependent phenotypes and transcriptional features of Alzheimer’s disease

    Several iPSC-derived three-dimensional (3D) cultures have been generated to model Alzheimer’s disease (AD). While some AD-related phenotypes have been identified across these cultures, none of them could recap...

    Selene Lomoio, Ravi S. Pandey, Nicolas Rouleau, Beatrice Menicacci… in Molecular Psychiatry (2023)

  2. Article

    Open Access

    BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

    β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patie...

    WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen… in Molecular Neurodegeneration (2018)

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