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    BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

    Although JAK2 inhibitors were proposed to be beneficial in chronic myeloid leukemia, myeloid transformation and STAT5 activation in BCR-ABL–positive leukemias are JAK2 independent. Mechanistic investigations r...

    Oliver Hantschel, Wolfgang Warsch, Eva Eckelhart, Ines Kaupe… in Nature Chemical Biology (2012)