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  1. No Access

    Article

    Vav3 regulates osteoclast function and bone mass

    Osteoporosis, a leading cause of morbidity in the elderly, is characterized by progressive loss of bone mass resulting from excess osteoclastic bone resorption relative to osteoblastic bone formation. Here we ...

    Roberta Faccio, Steven L Teitelbaum, Keiko Fujikawa, Jean Chappel… in Nature Medicine (2005)

  2. No Access

    Article

    Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

    The DNA-end-joining reactions used for repair of double-strand breaks in DNA and for V (D)J recombination, the process by which immunoglobulin and T-cell antigen-receptor genes are assembled from multiple gene se...

    Karen M. Frank, JoAnn M. Sekiguchi, Katherine J. Seidl, Wojciech Swat… in Nature (1998)

  3. No Access

    Article

    Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

    THE product of the vav proto-oncogene1, p95vav or Vav, is tyrosine phosphorylated upon stimulation of T and B cells by antigen2–4 and other5–8 receptors, and contains motifs associated with signal transduction1,9...

    Rong Zhang, Frederick W. Alt, Laurie Davidson, Stuart H. Orkin, Wojciech Swat in Nature (1995)

  4. No Access

    Article

    Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

    ONE mechanism ensuring self tolerance of T cells is the clonal deletion of thymocytes bearing αβ T-cell receptors1–4. The stage of thymocyte development at which the interaction with antigen-presenting cells (APC...

    Wojciech Swat, Leszek Ignatowicz, Harald von Boehmer, Pawel Kisielow in Nature (1991)