Skip to main content

3 Result(s)

within William G. O’Brien III Remove this filter

and

  1. Article

    Open Access

    5’-adenosine monophosphate mediated cooling treatment enhances ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) stability in vivo

    Gene mutations that produce misprocessed proteins are linked to many human disorders. Interestingly, some misprocessed proteins retained their biological function when stabilized by low temperature treatment o...

    Yueqiang Zhang, William G. O’Brien III, Zhaoyang Zhao… in Journal of Biomedical Science (2015)

    Download PDF (2120 KB) View Article

  2. Article

    Open Access

    CD73 and AMPD3 deficiency enhance metabolic performance via erythrocyte ATP that decreases hemoglobin oxygen affinity

    Erythrocytes are the key target in 5′-AMP induced hypometabolism. To understand how regulation of endogenous erythrocyte AMP levels modulates systemic metabolism, we generated mice deficient in both CD73 and A...

    William G. O’Brien III, Vladimir Berka, Ah-Lim Tsai, Zhaoyang Zhao… in Scientific Reports (2015)

    Download PDF (1077 KB) View Article

  3. No Access

    Article

    Metabolite profiling of 5′-AMP induced hypometabolism

    We have previously demonstrated that 5′-adenosine monophosphate (5′-AMP) can be used to induce deep hypometabolism in mice and other non-hibernating mammals. This reversible 5′-AMP induced hypometabolism (AIHM...

    Zhaoyang Zhao, Anita Van Oort, Zhenyin Tao, William G. O’Brien III… in Metabolomics (2014)