14 Result(s)

Article

Burn related injuries: a nationwide analysis of adult inter-facility transfers over a six-year period in the United States

US emergency department (ED) visits for burns and factors associated with inter-facility transfer are unknown and described in this manuscript.

Christopher S. Evans, Kimberly Hart, Wesley H. Self, Sayeh Nikpay… in BMC Emergency Medicine (2022)

Article

Differential neutralization and inhibition of SARS-CoV-2 variants by antibodies elicited by COVID-19 mRNA vaccines

The evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the emergence of new variant lineages that have exacerbated the COVID-19 pandemic. Some of those variants were desi...

Li Wang, Markus H. Kainulainen, Nannan Jiang, Han Di… in Nature Communications (2022)

Article

Trial of Early Antiviral Therapies during Non-hospitalized Outpatient Window (TREAT NOW) for COVID-19: a summary of the protocol and analysis plan for a decentralized randomized controlled trial

Coronavirus disease 2019 (COVID-19) has a heterogeneous outcome in individuals from remaining asymptomatic to death. In a majority of cases, mild symptoms are present that do not require hospitalization and ca...

Alexander M. Kaizer, Jessica Wild, Christopher J. Lindsell, Todd W. Rice… in Trials (2022)

Article

Passive Immunity Trial for Our Nation (PassITON): study protocol for a randomized placebo-control clinical trial evaluating COVID-19 convalescent plasma in hospitalized adults

Convalescent plasma is being used widely as a treatment for coronavirus disease 2019 (COVID-19). However, the clinical efficacy of COVID-19 convalescent plasma is unclear.

Wesley H. Self, Thomas G. Stewart, Allison P. Wheeler, Wissam El Atrouni… in Trials (2021)

Article

Effect of balanced crystalloids versus saline on urinary biomarkers of acute kidney injury in critically ill adults

Recent trials have suggested use of balanced crystalloids may decrease the incidence of major adverse kidney events compared to saline in critically ill adults. The effect of crystalloid composition on biomark...

Blake E. Funke, Karen E. Jackson, Wesley H. Self, Sean P. Collins… in BMC Nephrology (2021)

Article

A call for collaboration and consensus on training for endotracheal intubation in the medical intensive care unit

Endotracheal intubation (EI) is a potentially lifesaving but high-risk procedure in critically ill patients. While the ACGME mandates that trainees in pulmonary and critical care medicine (PCCM) achieve compet...

Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson… in Critical Care (2020)

Article

Big Data for Clinical Trials: Automated Collection of SpO₂ for a Trial of Oxygen Targets during Mechanical Ventilation

Kevin G. Buell, Jonathan D. Casey, Li Wang… in Journal of Medical Systems (2020)

Article

Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop

Conducting research in critically-ill patient populations is challenging, and most randomized trials of critically-ill patients have not achieved pre-specified statistical thresholds to conclude that the inter...

Michael O. Harhay, Jonathan D. Casey, Marina Clement… in Intensive Care Medicine (2020)

Article

Identification and validation of biomarkers of persistent acute kidney injury: the RUBY study

The aim of the RUBY study was to evaluate novel candidate biomarkers to enable prediction of persistence of renal dysfunction as well as further understand potential mechanisms of kidney tissue damage and repa...

Eric Hoste, Azra Bihorac, Ali Al-Khafaji, Luis M. Ortega… in Intensive Care Medicine (2020)

Article

How I manage a difficult intubation

Jonathan D. Casey, Matthew W. Semler, Kevin High, Wesley H. Self in Critical Care (2019)

Article

Saline versus balanced crystalloids for intravenous fluid therapy in the emergency department: study protocol for a cluster-randomized, multiple-crossover trial

Prior studies in critically ill patients suggest the supra-physiologic chloride concentration of 0.9% (“normal”) saline may be associated with higher risk of renal failure and death compared to physiologically...

Wesley H. Self, Matthew W. Semler, Jonathan P. Wanderer, Jesse M. Ehrenfeld… in Trials (2017)

Article

Balanced crystalloids versus saline in the intensive care unit: study protocol for a cluster-randomized, multiple-crossover trial

Saline, the intravenous fluid most commonly administered to critically ill adults, contains a high chloride content, which may be associated with acute kidney injury and death. Whether using balanced crystallo...

Matthew W. Semler, Wesley H. Self, Li Wang, Daniel W. Byrne, Jonathan P. Wanderer… in Trials (2017)

Article

Identification of Major Adverse Kidney Events Within the Electronic Health Record

Acute kidney injury is common among critically ill adults and is associated with increased mortality and morbidity. The Major Adverse Kidney Events by 30 days (MAKE30) composite of death, new renal replacement...

Matthew W. Semler, Todd W. Rice, Andrew D. Shaw… in Journal of Medical Systems (2016)

Article

Diabetes in the Emergency Department and Hospital: Acute Care of Diabetes Patients

Diabetes is a common condition, afflicting more than 20 % of the American population over the age of 60 years. Patients with diabetes, particularly those with lower socioeconomic status or limited access to pr...

William Ford, Wesley H. Self, Corey Slovis… in Current Emergency and Hospital Medicine Re… (2013)