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Article
Deficiency of betaine-homocysteine methyltransferase activates glucose-6-phosphate dehydrogenase (G6PD) by decreasing arginine methylation of G6PD in hepatocellular carcinogenesis
Betaine-homocysteine methyltransferase (BHMT) regulates protein methylation and is correlated with tumorigenesis; however, the effects and regulation of BHMT in hepatocarcinogenesis remain largely unexplored. ...
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Article
Open AccessPhosphoglycerate mutase 5 exacerbates liver ischemia–reperfusion injury by activating mitochondrial fission
Although the death of hepatocytes is a crucial trigger of liver ischemia–reperfusion (I/R) injury, the regulation of liver I/R-induced hepatocyte death is still poorly understood. Phosphoglycerate mutase 5 (PG...
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Article
Open AccessNFKBIZ regulates NFκB signaling pathway to mediate tumorigenesis and metastasis of hepatocellular carcinoma by direct interaction with TRIM16
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence and mortality rates. NFKBIZ, a member of the nuclear factor kappa B inhibitory family, is closely related to tumor progression. However, ...
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Article
Open Access“Access to pharmacy services is difficult in China”: a qualitative study from the perspective of transplant recipients to explore their expectations
To gain an in-depth and comprehensive understanding of Chinese organ transplant recipients’ perceptions, expectations, and suggestions of pharmacy services to hospital pharmacists.
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Article
Open AccessNovel molecular hepatocellular carcinoma subtypes and RiskScore utilizing apoptosis-related genes
Hepatocellular carcinoma (HCC) is the third leading cause of global cancer-related deaths. Despite immunotherapy offering hope for patients with HCC, only some respond to it. However, it remains unclear how to...
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Article
Open AccessNovel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
Non-coding RNA has aroused great research interest recently, they play a wide range of biological functions, such as regulating cell cycle, cell proliferation, and intracellular substance metabolism. Piwi-inte...
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Article
Associations of cadmium exposure with risk of metabolic syndrome and its individual components: a meta-analysis
Data directly associating cadmium (Cd) with metabolic syndrome (MetS) are sparse and inconsistent. We aimed to quantitatively assess the association of Cd exposure with risk of MetS and its individual componen...
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Article
Development of a New Rockbolt with High Load and Large Deformation Capacities
A new rockbolt for rock support in deep underground engineering is developed. The bolt, which is called 2S-bolt, is composed of a threadbar, a sliding piston, a sliding-resistance cone pipe, an anchorage secti...
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Article
Open AccessMitogen activated protein kinase phosphatase 5 alleviates liver ischemia–reperfusion injury by inhibiting TAK1/JNK/p38 pathway
Mitogen activated protein kinase phosphatase 5 (MKP5) is a member of the MKP family and has been implicated in diverse biological and pathological conditions. However, it is unknown what role MKP5 plays in liv...
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Article
Open AccessOverview of microbial profiles in human hepatocellular carcinoma and adjacent nontumor tissues
Intratumoral microbial communities have been recently discovered to exist in a variety of cancers and have been found to be intricately involved in tumour progression. Therefore, investigating the profiles and...
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Article
Open AccessDysfunctional epigenetic protein-coding gene-related signature is associated with the prognosis of pancreatic cancer based on histone modification and transcriptome analysis
Emerging evidence suggests that epigenetic alterations are responsible for the oncogenesis and progression of cancer. However, the role of epigenetic reprogramming in pancreatic cancer is still not clear. In t...
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Article
Open AccessA novel classification of HCC basing on fatty-acid-associated lncRNA
Aberrant long noncoding RNA (lncRNA) expression and fatty acid signaling dysfunction both contribute to hepatocellular carcinoma (HCC) occurrence and development. However, the relationship and interaction mech...
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Article
Open AccessMolecular characteristics of novel immune subtypes of HCC based on lncRNAs related to immune disorders
As one of the most malignant cancers and despite various treatment breakthroughs, the prognosis of hepatocellular carcinoma (HCC) remains unsatisfactory. The immune status of the tumor microenvironment (TME) r...
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Article
Magnesium intake is inversely associated with risk of non-alcoholic fatty liver disease among American adults
Human data are limited linking magnesium (Mg) intake to the risk of non-alcoholic fatty liver disease (NAFLD). We aimed to examine the association between Mg intake and the risk of NAFLD among young adults in ...
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Article
Cadmium Exposure in Young Adulthood Is Associated with Risk of Nonalcoholic Fatty Liver Disease in Midlife
Studies have suggested that cadmium (Cd) may be involved in the etiology of nonalcoholic fatty liver disease (NAFLD), but available data in human is sparse.
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Article
Open AccessDopamine and dopamine receptor D1 as a novel favourable biomarker for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) remains one of the most common malignant tumours worldwide. Therefore, the identification and development of sensitivity- genes as novel diagnostic markers and effective therapeu...
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Article
Open AccessPredictive value of m5C regulatory gene expression in pancreatic adenocarcinoma
Pancreatic adenocarcinoma (PAAD) is the most malignant digestive tumor. The global incidence of pancreatic cancer has been rapidly trending upwards, necessitating an exploration of potential prognostic biomark...
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Article
Open AccessPan-cancer analysis of m5C regulator genes reveals consistent epigenetic landscape changes in multiple cancers
5-Methylcytosine (m5C) is a reversible modification to both DNA and various cellular RNAs. However, its roles in develo** human cancers are poorly understood, including the effects of mutant m5C regulators and ...
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Article
Open AccessLINC00261: a burgeoning long noncoding RNA related to cancer
Long noncoding RNAs (lncRNAs), are transcripts longer than 200 nucleotides that are considered to be vital regulators of many cellular processes, particularly in tumorigenesis and cancer progression. long inte...
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Article
Open AccessSingle nucleotide polymorphisms in interleukin-6 attenuates hepatocytes injury in hypoxia/re-oxygenation via STAT3 signal pathway mediated autophagy
Ischemia-reperfusion injury (IRI) is inevitable during liver surgery, and it is an important factor affecting the prognosis of patients. IL-6 rs1800796 single nucleotide polymorphisms (SNPs) can promote synthesis...
