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  1. Article

    Open Access

    RNF8 is responsible for ATRA resistance in variant acute promyelocytic leukemia with GTF2I/RARA fusion, and inhibition of the ubiquitin–proteasome pathway contributes to the reversion of ATRA resistance

    GTF2I-RARA is a newly identified RARA fusion gene in variant acute promyelocytic leukemia (APL) patients with t(7;17)(q11;q21). Clinical manifestation in the patient showed that it is a sort of ATRA-insensitive o...

    Wenzhe Yan, Ji Li, Yang Zhang, Yafei Yin, Zhao Cheng… in Cancer Cell International (2019)

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    Article

    Functional Role of SUV39H1 in Human Renal Tubular Epithelial Cells Under High-glucose Ambiance

    SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional repressor of inflammatory genes. The effect of SUV39H1 on inflammatory gene promoters...

    Jiayi Wang, Wenzhe Yan, **aofei Peng, Yafeng Jiang, Liyu He, Youming Peng… in Inflammation (2018)