9 Result(s)

Article

ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

ABCA7 loss-of-function variants are associated with increased risk of Alzheimer’s disease (AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we investigated the impacts of ABCA7 deficiency o...

Keiji Kawatani, Marie-Louise Holm, Skylar C. Starling… in Molecular Psychiatry (2024)

Article

WGCNA and transcriptome profiling reveal hub genes for key development stage seed size/oil content between wild and cultivated soybean

Soybean is one of the most important oil crops in the world. The domestication of wild soybean has resulted in significant changes in the seed oil content and seed size of cultivated soybeans. To better unders...

Yanjie Yao, Erhui **ong, Xuelian Qu, Junfeng Li, Hongli Liu, Leipo Quan… in BMC Genomics (2023)

Article

APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for Alzheimer’s disease (AD); however, how it modulates brain homeostasis is not clear. The apoE protein is a major lipid carrier in the brain...

**g Zhao, Tadafumi C. Ikezu, Wenyan Lu, Jesse R. Macyczko… in Stem Cell Research & Therapy (2023)

Article

LRP1 is a neuronal receptor for α-synuclein uptake and spread

The aggregation and spread of α-synuclein (α-Syn) protein and related neuronal toxicity are the key pathological features of Parkinson’s disease (PD) and Lewy body dementia (LBD). Studies have shown that patho...

Kai Chen, Yuka A. Martens, Axel Meneses, Daniel H. Ryu… in Molecular Neurodegeneration (2022)

Article

Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids

**g Zhao, Wenyan Lu, Yingxue Ren, Yuan Fu, Yuka A. Martens… in Acta Neuropathologica (2022)

Article

Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids

APOE4 is a strong genetic risk factor for Alzheimer’s disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear. Here using human iPSC-...

**g Zhao, Wenyan Lu, Yingxue Ren, Yuan Fu, Yuka A. Martens… in Acta Neuropathologica (2021)

Article

Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

**g Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis… in Nature Communications (2021)

Article

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (iPSCs...

**g Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis… in Nature Communications (2020)

Article

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens

As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of N...

Bini Mathew, Judith V. Hobrath, Wenyan Lu, Yonghe Li… in Medicinal Chemistry Research (2017)