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  1. Article

    Open Access

    The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition

    Renal fibrosis is a prevalent manifestation of chronic kidney disease (CKD), and effective treatments for this disease are currently lacking. Myofibroblasts, which originate from interstitial fibroblasts, aggr...

    Qianyi Bao, Anyu Wang, Wenxuan Hong, Yushu Wang… in Cell Communication and Signaling (2024)

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  2. Article

    Open Access

    GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression

    Regulatory T cells (Tregs) are critically involved in neovascularization, an important compensatory mechanism in peripheral artery disease. The contribution of G protein coupled receptor 174 (GPR174), which is...

    ** Liu, Lihong Pan, Wenxuan Hong, Siqin Chen, Peiyuan Bai… in Nature Communications (2022)

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  3. Article

    Open Access

    HES5-mediated repression of LIGHT transcription may contribute to apoptosis in hepatocytes

    Non-alcoholic fatty liver disease (NAFLD) is prototypical form of metabolic syndrome and has become a global pandemic. Hepatocytes undergo apoptosis in the pathogenesis of NAFLD. We report that the lymphokine ...

    **ulian Miao, Yan Guo, Sheng Zeng, **ngyu Liu, **ao Teng, Luyang Li… in Cell Death Discovery (2021)

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  4. No Access

    Article

    Ablation of serum response factor in hepatic stellate cells attenuates liver fibrosis

    Trans-differentiation, or activation, of hepatic stellate cells (HSCs) is a hallmark event in liver fibrosis although the underlying mechanism is not fully appreciated. Serum response factor (SRF) is a pleiotr...

    Ming Kong, Wenxuan Hong, Yang Shao, Fangqiao Lv… in Journal of Molecular Medicine (2019)