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Article
Open AccessDesign and characterization of metallic glass/graphene multilayer with excellent nanowear properties
The excellent properties of metallic glass (MG) films make them perfect candidates for the use in miniature systems and tools. However, their high coefficients of friction (COFs) and poor wear resistance consi...
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Article
The Emerging Key Role of Klotho in the Hypothalamus–Pituitary–Ovarian Axis
The hypothalamus–pituitary–ovary axis is the most important system for regulating female reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of gonadotropin-releasing hormone,...
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Article
One-pot Multicomponent Synthesis of Highly Functionalized 1,4-Dihydropyridines Using Porcine Pancreatic Lipase
A series of highly functionalized 1,4-dihydropyridines was synthesized via one-pot multicomponent reactions of aromatic aldehyde, malononitrile and N-methyl-1-(methylthio)-2-nitroethenamine using Porcine pancreat...
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Article
Application of Enzymatic Promiscuity in Pharmaceutical Synthesis: Papain-catalyzed One-pot Synthesis of 1,4-Dihydropyridine Calcium Channel Antagonists and Derivatives
A new method for the synthesis of 1,4-dihydropyridine(1,4-DHP) calcium channel antagonists felodipine, nitrendipine and their derivatives via papain-catalyzed three-component reactions of aldehyde, methyl acetoac...