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Article
Open AccessGenerating diverse clothed 3D human animations via a generative model
Data-driven garment animation is a current topic of interest in the computer graphics industry. Existing approaches generally establish the map** between a single human pose or a temporal pose sequence, and ...
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Article
Alcohol-driven metabolic reprogramming promotes development of RORγt-deficient thymic lymphoma
RORγt is a master regulator of Th17 cells. Despite evidence linking RORγt deficiency/inhibition with metastatic thymic T cell lymphomas, the role of RORγt in lymphoma metabolism is unknown. Chronic alcohol con...
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Article
Open AccessEmbryonic exposure to ethanol increases the susceptibility of larval zebrafish to chemically induced seizures
Prenatal ethanol exposure is known to cause neurodevelopmental disorders. While high prevalence of epilepsy is observed among the children whose mothers abused alcohol during pregnancy, the results from animal...
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Article
Open AccessActivation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling
Autophagy serves as a protective mechanism to degrade damaged organelles and proteins. Acute alcohol exposure is known to activate the hepatic autophagy response, whereas chronic alcohol exposure slows autopha...
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Article
Up-regulation of Siah1 by ethanol triggers apoptosis in neural crest cells through p38 MAPK-mediated activation of p53 signaling pathway
Seven in absentia homolog 1 (Siah1) is one of the E3 ubiquitin ligases and plays a key role in regulating target protein degradation. This study was designed to test the hypothesis that Siah1 mediates ethanol-...
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The Impact of Gut Microbiota on Liver Injury
Alterations in gut microbiota in patients with chronic liver diseases were first noted more than 80 years ago. Increasing translocation of microbial products from the leaky gut is considered one of the major c...
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Article
Open AccessFibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver. We sought to determine the role of FGF21 in hepatic steatosis in mice exposed to chronic alcohol tr...
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Article
Fibroblast growth factor 21 protects the heart from apoptosis in a diabetic mouse model via extracellular signal-regulated kinase 1/2-dependent signalling pathway
This study investigated fibroblast growth factor 21 (FGF21)-mediated cardiac protection against apoptosis caused by diabetic lipotoxicity and explored the protective mechanisms involved.
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Article
Open AccessFibroblast growth factor 21 deletion aggravates diabetes-induced pathogenic changes in the aorta in type 1 diabetic mice
Fibroblast growth factor 21 (FGF21) is an important regulator in glucose and lipid metabolism, and has been considered as a potential therapy for diabetes. The effect of FGF21 on the development and progressio...
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Article
PEGylated rhFGF-2 Conveys Long-term Neuroprotection and Improves Neuronal Function in a Rat Model of Parkinson’s Disease
Fibroblast growth factor 2 (FGF-2) has a neurotrophic effect on dopaminergic neurons in vitro and in vivo, and exhibits beneficial effects in animal models of neurodegenerative disorders such as Parkinson’s di...
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Article
Expression and Purification of Human Keratinocyte Growth Factor 2 by Fusion with SUMO
Small ubiquitin-related modifier (SUMO) fusion system has been shown to be efficient for enhancing expression and preventing degradation of the target protein. We showed herein that SUMO fusion to human kerati...
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Article
Large-scale production of biologically active human keratinocyte growth factor-2
A rapid and efficient expression and purification system has been developed for large-scale production of biologically active recombinant human keratinocyte growth factor-2 (rhKGF-2). The gene encoding human K...
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Article
High-level expression and purification of Tat-haFGF19-154
Human acidic fibroblast growth factor (haFGF) stimulates repair and regeneration of central and peripheral nerves after various injuries. However, it is unable to cross the blood–brain barrier (BBB). To produc...
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Article
High level expression of human endostatin in Pichia pastoris using a synthetic gene construct
Endostatin, a 20-kDa C-terminal fragment derived from type XVIII collagen, is a potent angiogenesis inhibitor and an antitumor factor. To improve the production of recombinant human endostatin on increasing de...
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Article
Environmental changes in the eastern China during the Late Pleistocene
The environmental changes during the Late Pleistocene were more obvious in the eastern China than in other areas at the same latitude, which either between northern and southern, or between land and sea of the...
