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  1. Article

    Open Access

    Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates

    Genetic encoding of noncanonical amino acid (ncAA) for site-specific protein modification has been widely applied for many biological and therapeutic applications. To efficiently prepare homogeneous protein mu...

    Yong Wang, **gming Zhang, Boyang Han, Linzhi Tan, Wenkang Cai… in Nature Communications (2023)

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    Protein Expression with Biosynthesized Noncanonical Amino Acids

    Natural proteins are normally made by 20 canonical amino acids. Genetic code expansion (GCE) enables incorporation of diverse chemically synthesized noncanonical amino acids (ncAAs) by orthogonal aminoacyl-tRN...

    Yong Wang, Wenkang Cai, Boyang Han, Tao Liu in Genetically Incorporated Non-Canonical Ami… (2023)