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Open AccessEstablishment of the prognostic index of lung squamous cell carcinoma based on immunogenomic landscape analysis
The incidence of lung squamous cell carcinoma (LUSC) increased substantially in recent years. Systematical investigation of the immunogenomic pattern is critical to improve the prognosis of LUSC.
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Article
Open AccessThe long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68
Long non-coding RNAs (lncRNAs) function as key molecules in cancer progression. The lncRNA CYTOR plays oncogenic roles in multiple types of cancer, yet the detailed molecular mechanisms of those roles remain u...
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Article
Mutations of key driver genes in colorectal cancer progression and metastasis
The association between mutations of key driver genes and colorectal cancer (CRC) metastasis has been investigated by many studies. However, the results of these studies have been contradictory. Here, we perfo...
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Open AccessErratum to: Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p
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Open AccessLong non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p
The function of a new long non-coding RNA linc00673 remains unclear. While identified as an oncogenic player in non-small cell lung cancer (NSCLC), linc00673 was found to be anti-oncogenic in pancreatic ductal...
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Article
Hemocompatibility of folic-acid-conjugated amphiphilic PEG-PLGA copolymer nanoparticles for co-delivery of cisplatin and paclitaxel: treatment effects for non-small-cell lung cancer
In this study, we used folic-acid-modified poly(ethylene glycol)-poly(lactic-co-glycolic acid) (FA-PEG-PLGA) to encapsulate cisplatin and paclitaxel (separately or together), and evaluated their antitumor effe...
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Erratum to: Methylation of the miR-126 gene associated with glioma progression
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Methylation of the miR-126 gene associated with glioma progression
Gliomas are the most common and the most malignant brain tumors, accouting for 45–55 % of all intracranial tumors. The incidence of glioma worldwide is about 6–12 per 100,000. Recently, several studies showed...
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Article
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation
Transcriptional reactivation of TERT, the catalytic subunit of telomerase, is necessary for cancer progression in about 90% of human cancers. The recent discovery of two prevalent somatic mutations—C250T and C...
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Article
Open AccessAdjuvant therapy for T3N0 rectal cancer in the total mesorectal excision era- identification of the high risk patients
Adjuvant therapy for T3N0 rectal cancer was controversial with respect to both radiation and the use of a combined regimen of chemotherapy. We evaluated both clinical features and biomarkers and sought to dete...
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Open AccessProposing the lymphatic target volume for elective radiation therapy for pancreatic cancer: a pooled analysis of clinical evidence
Radiation therapy is an important cancer treatment modality in both adjuvant and definitive setting, however, the use of radiation therapy for elective treatment of regional lymph nodes is controversial for pa...