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    Article

    The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents

    To improve the treatment of breast cancer, there has been a need for alternative aromatase inhibitors (AIs) that bring about adequate aromatase inhibition, while limiting side effects. Since two tamoxifen meta...

    Wenjie Jessie Lu, Cong Xu, Zifan Pei… in Breast Cancer Research and Treatment (2012)

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    Article

    Tamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer

    The mechanism of tamoxifen action in the treatment of breast cancer is believed to be via active metabolites that act as potent estrogen receptor antagonists. Attempts to identify relationships between active ...

    Wenjie Jessie Lu, Zeruesenay Desta… in Breast Cancer Research and Treatment (2012)