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Article
Open AccessPD-L1 inhibitor versus PD-1 inhibitor plus bevacizumab with transvascular intervention in unresectable hepatocellular carcinoma
Both atezolizumab (a PD-L1 inhibitor) plus bevacizumab (A+B) and sintilimab (a PD-1 inhibitor) plus bevacizumab (S+B) are recommended as the first-line regimen for advanced hepatocellular carcinoma (HCC) in Ch...
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Article
Open AccessUnveiling divergent treatment prognoses in IDHwt-GBM subtypes through multiomics clustering: a swift dual MRI-mRNA model for precise subtype prediction
IDH1-wildtype glioblastoma multiforme (IDHwt-GBM) is a highly heterogeneous and aggressive brain tumour characterised by a dismal prognosis and significant challenges in accurately predicting patient outcomes....
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Article
Open AccessMachine learning-based pathomics signature of histology slides as a novel prognostic indicator in primary central nervous system lymphoma
To develop and validate a pathomics signature for predicting the outcomes of Primary Central Nervous System Lymphoma (PCNSL).
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Article
Automatic image segmentation and online survival prediction model of medulloblastoma based on machine learning
To develop a dynamic nomogram containing radiomics signature and clinical features for estimating the overall survival (OS) of patients with medulloblastoma (MB) and design an automatic image segmentation mode...
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Article
Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder
Attention-deficit/hyperactivity disorder (ADHD) commonly precedes the initial onset of mania in youth with familial risk for bipolar disorder (BD). Although ADHD youth with and without BD familial risk exhibit...
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Article
Open AccessA protein network refinement method based on module discovery and biological information
The identification of essential proteins can help in understanding the minimum requirements for cell survival and development to discover drug targets and prevent disease. Nowadays, node ranking methods are a ...
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Article
Open AccessGlioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications
Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Tar...
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Article
Open AccessUncertainties of landslide susceptibility prediction: influences of different study area scales and map** unit scales
This study aims to investigate the effects of different map** unit scales and study area scales on the uncertainty rules of landslide susceptibility prediction (LSP). To illustrate various study area scales,...
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Article
Electrolyte-gated SrCoOx FET sensor for highly sensitive detecting pH in extreme alkalinity solution
The pH monitoring is significantly important in chemical industry, biological process, and pollution treatment. However, it remains a great challenge to measure pH in extreme alkalinity conditions. Herein, we ...
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Article
Open AccessOrigin and evolution of false brinelling and fretting corrosion under rolling conditions
Rolling bearings working in oscillating applications often suffer from false brinelling and fretting corrosion that limit their service life. At present, the study of oscillation-induced failures is primarily ...
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Article
Ceftriaxone Modulates Ubiquitination of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous β-Amyloid in a Glutamate Transporter-1 Dependent Manner
Α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are crucial for properties of synaptic plasticity, such as long-term potentiation (LTP). LTP impairment can occur early in the onset of ...
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Article
Open AccessSulbactam protects neurons against double neurotoxicity of amyloid beta and glutamate load by upregulating glial glutamate transporter 1
Amyloid beta (Abeta) synergistically enhances excitotoxicity of glutamate load by impairing glutamate transporter 1 (GLT1) expression and function, which exacerbates the development of Alzheimer’s disease (AD)...
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Article
Author Correction: Aerial additive manufacturing with multiple autonomous robots
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Article
Synthesis of 2D perovskite crystals via progressive transformation of quantum well thickness
Two-dimensional (2D) multilayered halide perovskites have emerged as a platform for understanding organic–inorganic interactions, tuning quantum confinement effects and realizing efficient and durable optoelec...
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Article
Effect of microstructures tuning on mechanical properties of an ultra-high strength marine steel via the TRIP effect
In this study, we investigated the impact of microstructures tuning on the mechanical properties of marine steel, focusing on the role of retained austenite (RA) in achieving superior strength-plasticity syner...
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Open AccessCorrection to: Increased co-expression of PD1 and TIM3 is associated with poor prognosis and immune microenvironment heterogeneity in gallbladder cancer
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Article
Open AccessDeep learning for classifying the stages of periodontitis on dental images: a systematic review and meta-analysis
The development of deep learning (DL) algorithms for use in dentistry is an emerging trend. Periodontitis is one of the most prevalent oral diseases, which has a notable impact on the life quality of patients....
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Article
Experimental Investigation into the Effect of Process Parameters on the Drilling Performance for Swirling Impeller Abrasive Water Jet
Radial jet drilling (RJD) is an innovative geological resource development technology. Swirling impeller abrasive water jet (SAWJ) is an excellent rock drilling method and is expected to drill larger branches ...
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Article
Open AccessBioinspired porous three-coordinated single-atom Fe nanozyme with oxidase-like activity for tumor visual identification via glutathione
Inspired by structures of natural metalloenzymes, a biomimetic synthetic strategy is developed for scalable synthesis of porous Fe-N3 single atom nanozymes (pFeSAN) using hemoglobin as Fe-source and template. pFe...
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Open AccessNitrate attenuates cisplatin-induced acute kidney injury by promotion of mitophagy and reduction of oxidative stress
Cisplatin, an anticancer drug, has limited its clinical application due to its severe nephrotoxicity, such as acute kidney injury (AKI). Damaged or dysfunctional mitochondria caused by cisplatin are toxic to t...
