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Wen-** Chen
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Article
A universal polymer-assisted route to fabricate Zr-doped TiO2 nanocomposite: boosting reactive desulfurization
A series of transition metal ion-doped TiO2 composites were prepared by polyethyleneimine-assisted solvent-free self-assembly. Due to the similar electronegativity and ionic radius of Ti and Zr ions, the introduc...
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Temperate Stutzerimonas Phage Encoding Toxin-Antitoxin System Genes Represents a Novel Genus
Stutzerimonas have been extensively studied due to their remarkable metabolic and physiological diversity. However, research on its phages is currently limited. In this study, we isolated a novel double-stranded ...
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Cimifugin Mechanism of Action from Saposhnikovia divaricata in the Treatment of Atopic Dermatitis
The present study aimed to explore the mechanism of action of cimifugin, the primary active ingredient in Saposhnikovia divaricata (Turcz.) Schischk., Apiaceae, in treating atopic dermatitis. BALB/c mice were gro...
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Atypical phenotypes and novel OCRL variations in southern Chinese patients with Lowe syndrome
Lowe syndrome is characterized by the presence of congenital cataracts, psychomotor retardation, and dysfunctional proximal renal tubules. This study presents a case of an atypical phenotype, investigates the ...
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Exploring the Correlation Between Surface Roughness, Surface Energy, Nano-indentation, Electrical Properties, and Magnetic Characteristics of Annealed Co40Fe40Dy20 Thin Films Deposited on Si(100) Substrates
The impact of film thickness and annealing temperature on the structural, electrical, magnetic, and mechanical properties of cobalt–iron–dysprosium (Co40Fe40Dy20 ) thin films deposited on Si(100) substrates have...
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Open AccessCytological and ultrastructural investigation of pathogen infection pathway and host responses in asparagus stem infected by Phomopsis asparagi
Asparagus stem blight, a highly destructive disease in global asparagus cultivation, is caused by the fungus Phomopsis asparagi. However, the underlying mechanisms of the infectious process and pathogenesis of P....
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Open AccessKAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2
Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific ...
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Open AccessCorrection: PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target
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Mechanism Analysis of Selenium-Containing Compounds in Alleviating Spinal Cord Injury Based on Network Pharmacology and Molecular Docking Technology
Spinal cord injury (SCI) is a severe traumatic condition in spinal surgery characterized by nerve damage in and below the injured area. Despite advancements in understanding the pathophysiology of SCI, effecti...
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Open AccessIntegrative multi-omics analysis unravels the host response landscape and reveals a serum protein panel for early prognosis prediction for ARDS
The multidimensional biological mechanisms underpinning acute respiratory distress syndrome (ARDS) continue to be elucidated, and early biomarkers for predicting ARDS prognosis are yet to be identified.
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Open AccessRegioselective and enantioselective propargylic hydroxylations catalyzed by P450tol monooxygenases
Regioselective and enantioselective hydroxylation of propargylic C-H bonds are useful reactions but often lack appropriate catalysts. Here a green and efficient asymmetric hydroxylation of primary and secondar...
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Article
Open AccessVascular endothelial dysfunction induced by 3-bromofluoranthene via MAPK-mediated-NFκB pro-inflammatory pathway and intracellular ROS generation
3-Bromofluoranthene (3-BrFlu) is the secondary metabolite of fluoranthene, which is classified as a polycyclic aromatic hydrocarbon, through bromination and exists in the fine particulate matter of air polluta...
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Open AccessVBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor in East Asia. Hypoxia, a hallmark of solid tumors, significantly alters redox homeostasis inside tumor microenvironment. This alteration dr...
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Article
Acquired Fanconi syndrome in mixed cryoglobulinemia patients: a single-center case series
Cryoglobulinemia is a pathological condition characterized by the presence of cryoglobulins in the blood, with cryoglobulinemic glomerulonephritis being the most frequent form of renal involvement. Fanconi syn...
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Article
Absence of ultrasonic-vibration-induced plasticity in metallic glacial glasses
Metallic glasses (MGs) have been found to exhibit unexpected ultrasonic-vibration-induced plasticity (UVIP), which provides a promising way to realize room temperature processing and molding of MGs. However, w...
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Article
Conditional Survival of Patients with Limited-Stage Small Cell Lung Cancer After Surgery: A National Real-World Cohort Study
The prognosis of limited-stage small cell lung cancer (LS-SCLC) after surgery usually is estimated at diagnosis, but how the prognosis actually evolves over time for patients who survived for a predefined time...
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Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Open AccessRadiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells
Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...
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Magnetic emission intensity enhancement for amorphous alloys by constructing a multi-phase structure with α-Fe nanocrystals
The perturbation in the magnetic field generated by the rotation or oscillation of magnetic domains in magnetic materials can emit low-frequency electromagnetic waves, which are expected to be used in low-freq...
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Characteristics of super drought in Southwest China and the associated compounding effect of multiscalar anomalies
In recent decades, Southwest China (SWC) has suffered from frequent super droughts, leading to severe economic losses and ecological degradation. This study investigates the characteristics of super droughts i...
