-
Article
Open AccessThe involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice
Numerous studies have found that inhibiting the expression of NLRP3 inflammasome can significantly improve depressive-like behaviors in mice, but the research on its effect on cognitive decline in depression a...
-
Article
Open AccessHippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
Depression is one of the most common mental disorders characterized mainly by low mood and loss of interest or pleasure. About a third of patients with depression do not respond to classic antidepressant treat...
-
Article
Open AccessAntidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chro...