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Article
Damage evolution characteristics of 3D reconstructed bedding-containing shale based on CT technology and digital image processing
In order to construct a numerical simulation model that can reflect the bedding structure of real shale samples, CT scanning and digital image processing were utilized to analyze the intricate internal structu...
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Article
Open AccessOrigin recognition complex 6 overexpression promotes growth of glioma cells
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition comp...
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Article
Li1.5Al0.5Zr1.5(PO4)3-coated Li1.2Mn0.54Ni0.13Co0.13O2 cathode materials with high lithium-ion diffusion rate and long cycling stability for lithium-ion batteries
Lithium rich-layered oxides have attracted widespread attention due to their high specific capacity and high energy density. However, severe lithium nickel mixing, poor lithium-ion migration rate, and surface ...
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Article
Estimating China’s CO2 emissions under the influence of COVID-19 epidemic using a novel fractional multivariate nonlinear grey model
The COVID-19 pandemic has posed a severe challenge to the global economic recovery and China’s economic growth. Although China has achieved stage victory against the epidemic, the impact and influence of the e...
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Article
Surveillance of SARS-CoV-2 at the Huanan Seafood Market
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, emerged in December 2019. Its origins remain uncertain. It has been reported that a number of the ...
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Article
Characterization of Gut Microbiota in Rats and Rhesus Monkeys After Methamphetamine Self-administration
Methamphetamine (MA) is one of the most abused drugs globally, but the mechanism of its addiction remains unclear. Several animal studies have shown that the gut microbiota (GM) influences addictive behaviors,...
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Article
Open AccessNatural variation in BnaA07.MKK9 confers resistance to Sclerotinia stem rot in oilseed rape
Sclerotinia stem rot (SSR), caused by the necrotrophic fungus Sclerotinia sclerotiorum, is one of the most devastating diseases for several major oil-producing crops. Despite its impact, the genetic basis of SSR ...
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Article
Experimental study on the determination method of pressure relief gas transportation and storage channel under multiple factors
In the increasingly intense high-intensity mining process of coal mines, many factors comprehensively influence the spatial distribution characteristics of overburden fissure. The characteristics of overburden...
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Article
Seismic Signal Analysis Based on Adaptive Variational Mode Decomposition for High-speed Rail Seismic Waves
High-speed rails with determined length and load run for long periods at almost uniform speeds along fixed routes, constituting a new stable and repeatable artificial seismic source. Studies have demonstrated ...
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Article
3D Numerical Simulation Study of Brazilian Splitting in Calcite Vein-bearing Shale Based on CT Scans
Shale affects reservoir fracture sprouting and expansion during fracture modification. The aim of this study was to investigate the influence of calcite veins with distinct flaw inclinations on the stretch str...
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Article
Neuropilin-1high monocytes protect against neonatal inflammation
Neonates are susceptible to inflammatory disorders such as necrotizing enterocolitis (NEC) due to their immature immune system. The timely appearance of regulatory immune cells in early life contributes to the...
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Article
Open AccessDifferences between the intestinal microbial communities of healthy dogs from plateau and those of plateau dogs infected with Echinococcus
Cystic echinococcosis (CE) represents a profoundly perilous zoonotic disease. The advent of viral macrogenomics has facilitated the exploration of hitherto uncharted viral territories. In the scope of this inv...
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Article
Open AccessEnhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain
Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerg...
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Article
Open AccessIntranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2 inflammation. However, the underlying mechanism remains uncertai...
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Article
Tailoring the d-band center on Ru1Cu single-atom alloy nanotubes for boosting electrochemical non-enzymatic glucose sensing
The development of cost-effective and highly efficient electrocatalysts is critical to help electrochemical non-enzymatic sensors achieve high performance. Here, a new class of catalyst, Ru single atoms confin...
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Article
Open AccessBarriers and facilitators to guideline for the management of pediatric off-label use of drugs in China: a qualitative descriptive study
Despite being a global public health concern, there is a research gap in analyzing implementation strategies for managing off-label drug use in children. This study aims to understand professional health manag...
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Article
Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis
Recent studies have shown that cellular levels of polyamines (PAs) are significantly altered in neurodegenerative diseases. Evidence from in vivo animal and in vitro cell experiments suggests that the cellular le...
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Article
Open AccessA nomogram for predicting the risk of treatment failure of roxadustat in peritoneal dialysis with renal anemia
The determinants of roxadustat treatment failure in renal anemia remain elusive. This study sought to develop a nomogram for predicting the risk of treatment failure of roxadustat in peritoneal dialysis (PD) w...
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Article
A Weighted Hybridizable Discontinuous Galerkin Method for Drift-Diffusion Problems
In this work, we propose a weighted hybridizable discontinuous Galerkin method (W-HDG) for drift-diffusion problems. By using specific exponential weights when computing the
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Article
Open AccessBiosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol
Taxol is a widely-applied anticancer drug that inhibits microtubule dynamics in actively replicating cells. Although a minimum 19-step biosynthetic pathway has been proposed and 16 enzymes likely involved have...
